{"id":"W2046816092","doi":"10.1016/j.str.2013.06.012","title":"The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Terminal (telecommunication); Binding site; Mutation; Receptor; Chemistry; Biology; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003825523,0.0001261305,0.00007342995,0.00002410194,0.0003307216,0.00007989603,0.00008303182,0.0001161939,0.0001297251],"category_scores_gemma":[0.00002648324,0.0000913797,0.00006795093,0.00006813191,0.00006085969,0.00001732721,0.00002503131,0.00007439981,0.00002085074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000019668,"about_ca_system_score_gemma":0.00002816585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002058572,"about_ca_topic_score_gemma":0.000006251661,"domain_scores_codex":[0.999295,0.00006878511,0.0001054717,0.0002422345,0.0001201995,0.0001683057],"domain_scores_gemma":[0.9994497,0.000006848456,0.00007606286,0.0002377906,0.000102966,0.0001265905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001088842,0.00001343076,0.005590524,0.000008953441,0.00004452982,0.000001104033,0.0002059953,0.00003572961,0.8332105,0.0000586827,0.1554161,0.005305599],"study_design_scores_gemma":[0.001180363,0.0003906728,0.04565475,0.00002353834,0.00009995244,0.00002501131,0.001052794,0.002132305,0.3054055,0.0005923521,0.6427085,0.0007341595],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967221,0.0003683839,0.0004602301,0.001009955,0.0007861012,0.000275499,0.0003083055,0.0000211048,0.00004830498],"genre_scores_gemma":[0.9919175,0.00008503519,0.00005094931,0.0002798837,0.0005033245,0.00002194166,0.004384516,0.00001771798,0.002739125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5278049,"threshold_uncertainty_score":0.3726356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007839992611848173,"score_gpt":0.2275982391451319,"score_spread":0.2197582465332837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}