{"id":"W2046816092","doi":"10.1016/j.str.2013.06.012","title":"The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Terminal (telecommunication); Binding site; Mutation; Receptor; Chemistry; Biology; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268488,0.0007851136,0.0005900026,0.0003521597,0.0004677124,0.0003481692,0.0006686029,0.001381439,0.001915141],"category_scores_gemma":[0.0004211915,0.0002991862,0.0006557835,0.0002369211,0.0009007063,0.000323529,0.0005139327,0.000933622,0.001017857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584604,"about_ca_system_score_gemma":0.0004398408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064511,"about_ca_topic_score_gemma":0.001179126,"domain_scores_codex":[0.9997647,0.0000374253,0.00005119941,0.00006449415,0.00005883296,0.00002322646],"domain_scores_gemma":[0.9995461,0.00009001684,0.0002050401,0.00003928088,0.00003921894,0.00008029219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002923538,0.00003941661,0.0005539763,0.00008080314,0.00003506437,0.003472797,0.00006086046,0.00025576,0.9916614,0.0006563638,0.0002737874,0.002617344],"study_design_scores_gemma":[0.0003990477,0.000715951,0.03059053,0.00007369246,0.0002565941,0.04047164,0.0001144887,0.003905938,0.9068766,0.001001122,0.01549908,0.0000953937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795272,0.00147321,0.0132851,0.0006025435,0.0003050331,0.00009511264,0.001626587,0.0003117868,0.002773474],"genre_scores_gemma":[0.9906397,0.0004283407,0.005583177,0.0002388816,0.00007420198,0.00005395915,0.0008968432,0.00008440008,0.002000492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915141,"threshold_uncertainty_score":0.006406724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007839992611848173,"score_gpt":0.2275982391451319,"score_spread":0.2197582465332837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}