{"id":"W2046816494","doi":"10.1016/j.mehy.2015.01.044","title":"Paradigm shift redefining molecular, metabolic and structural events in Alzheimer’s disease involves a proposed contribution by transition metals. Defined lengthy preclinical stage provides new hope to circumvent advancement of disease- and age-related neurodegeneration","year":2015,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Intracellular; Amyloid (mycology); Extracellular; Amyloid precursor protein; Toxicity; Peptide; P3 peptide; Amyloid beta; Chemistry; Cell biology; Biochemistry; Disease; Neuroscience; Alzheimer's disease; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002778058,0.0006596926,0.0008153788,0.0008391864,0.0006184431,0.00224978,0.00117259,0.001540543,0.003300414],"category_scores_gemma":[0.00116196,0.0002100927,0.0005841756,0.0005037903,0.003013279,0.003582147,0.001457894,0.003639547,0.000883947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001535278,"about_ca_system_score_gemma":0.002887833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005300276,"about_ca_topic_score_gemma":0.0009172615,"domain_scores_codex":[0.9995211,0.0001329094,0.00003967131,0.0001266282,0.0001231031,0.0000565869],"domain_scores_gemma":[0.9987035,0.0004745747,0.0001798503,0.0001657612,0.0003384991,0.0001378564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001625294,0.0009085428,0.004874109,0.005300914,0.0001327374,0.0007042526,0.0009087599,0.001346183,0.2729547,0.4034981,0.01187115,0.2958752],"study_design_scores_gemma":[0.000193958,0.006654693,0.007932786,0.001380776,0.0003767351,0.003255575,0.001714898,0.003024106,0.2124201,0.4002651,0.3626232,0.0001580734],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1706523,0.5390099,0.1202075,0.1118808,0.007890236,0.0003390709,0.001200367,0.0008542521,0.04796575],"genre_scores_gemma":[0.5472581,0.3659265,0.05667327,0.01130648,0.005167601,0.0003549129,0.0006885721,0.0001164174,0.01250818],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003300414,"threshold_uncertainty_score":0.01469195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05322910500468927,"score_gpt":0.3307070583069135,"score_spread":0.2774779533022243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}