{"id":"W2046816494","doi":"10.1016/j.mehy.2015.01.044","title":"Paradigm shift redefining molecular, metabolic and structural events in Alzheimer’s disease involves a proposed contribution by transition metals. Defined lengthy preclinical stage provides new hope to circumvent advancement of disease- and age-related neurodegeneration","year":2015,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital","funders":"","keywords":"Intracellular; Amyloid (mycology); Extracellular; Amyloid precursor protein; Toxicity; Peptide; P3 peptide; Amyloid beta; Chemistry; Cell biology; Biochemistry; Disease; Neuroscience; Alzheimer's disease; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004660447,0.0002736443,0.0005727979,0.0001556903,0.00006054035,0.00002521381,0.00008435212,0.00009361666,0.00003523853],"category_scores_gemma":[0.001612064,0.000214823,0.00009553345,0.0002296074,0.0002168814,0.000211815,0.00006308692,0.0001843921,0.000002896226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005222824,"about_ca_system_score_gemma":0.0007164268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901981,"about_ca_topic_score_gemma":0.00004008066,"domain_scores_codex":[0.996984,0.0004092912,0.000613467,0.0005375272,0.001069303,0.0003864262],"domain_scores_gemma":[0.9971139,0.0001651394,0.000123593,0.0002390028,0.00005306308,0.002305314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1020324,0.01272195,0.5701287,0.002392716,0.03399276,0.006965538,0.008965433,0.001805704,0.007074548,0.0508915,0.0006147753,0.202414],"study_design_scores_gemma":[0.04358211,0.005188812,0.8883397,0.002057549,0.008584674,0.00003208728,0.0002316633,0.01426315,0.007246625,0.02831537,0.0008809474,0.001277316],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341227,0.05528723,0.000735737,0.007768454,0.00004710698,0.001854415,0.0001395184,0.00003975865,0.000005051402],"genre_scores_gemma":[0.997887,0.000897191,0.0002126052,0.0003515623,0.00003140743,0.0001180345,0.0004655581,0.00002922042,0.000007433202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.318211,"threshold_uncertainty_score":0.8760229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05322910500468927,"score_gpt":0.3307070583069135,"score_spread":0.2774779533022243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}