{"id":"W2046833185","doi":"10.1074/jbc.m303384200","title":"Receptor Trafficking via the Perinuclear Recycling Compartment Accompanied by Cell Division Is Necessary for Permanent Neurotensin Cell Sensitization and Leads to Chronic Mitogen-activated Protein Kinase Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer; Sanofi","keywords":"Cell biology; Receptor; Biology; Neurotensin receptor; Endocytosis; Cell surface receptor; Cell; Protein kinase A; Homologous desensitization; Agonist; Neurotensin; Kinase; Biochemistry; Neuropeptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361739,0.00019613,0.0002226161,0.00001722111,0.0001824812,0.00005672915,0.0001576579,0.0001980523,0.00003168293],"category_scores_gemma":[0.00005255227,0.000134759,0.0001217857,0.00006943232,0.00004033031,0.00001108423,0.0000736212,0.0001947479,0.000001120619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007807631,"about_ca_system_score_gemma":0.00004519993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002327219,"about_ca_topic_score_gemma":1.509343e-7,"domain_scores_codex":[0.9989096,0.00005221472,0.0003701099,0.000291306,0.0001557304,0.0002210689],"domain_scores_gemma":[0.9992555,0.00002845516,0.0003159498,0.0001320969,0.000147706,0.0001203114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002948438,0.00009416113,0.00002645226,0.00004556397,0.00001472512,0.000001054776,0.00008572256,0.001330817,0.9968104,5.821373e-7,0.0003839713,0.0009116818],"study_design_scores_gemma":[0.0009562621,0.0007234814,0.00006834724,0.00007120106,0.00001270138,0.00001257708,0.0001156513,0.0001636338,0.9946715,0.0000180619,0.003011172,0.000175382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903975,0.0003622771,0.007823034,0.000929115,0.00009793624,0.0003566011,0.00001180352,0.000007471274,0.00001426799],"genre_scores_gemma":[0.997921,0.00009723594,0.001157283,0.0002787461,0.0003890759,0.000009522551,0.00007750508,0.00002080365,0.00004883649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007523498,"threshold_uncertainty_score":0.5495314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455191996702564,"score_gpt":0.23721371607406,"score_spread":0.2226617961070343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}