{"id":"W2046833185","doi":"10.1074/jbc.m303384200","title":"Receptor Trafficking via the Perinuclear Recycling Compartment Accompanied by Cell Division Is Necessary for Permanent Neurotensin Cell Sensitization and Leads to Chronic Mitogen-activated Protein Kinase Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer; Sanofi","keywords":"Cell biology; Receptor; Biology; Neurotensin receptor; Endocytosis; Cell surface receptor; Cell; Protein kinase A; Homologous desensitization; Agonist; Neurotensin; Kinase; Biochemistry; Neuropeptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009594903,0.0001918569,0.0003945412,0.0001201961,0.0001530656,0.0003204458,0.0001582184,0.0001992591,0.0009892818],"category_scores_gemma":[0.0001035302,0.0001354608,0.0002062759,0.0001197689,0.0001690683,0.0002281183,0.0002163041,0.0003890885,0.0003666086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003222911,"about_ca_system_score_gemma":0.0002305582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007209796,"about_ca_topic_score_gemma":0.0009746022,"domain_scores_codex":[0.9998487,0.00001676741,0.00001564505,0.00004078588,0.00003113803,0.00004698089],"domain_scores_gemma":[0.9998764,0.00002203387,0.00003115484,0.0000271591,0.00001558741,0.00002770583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004479988,0.000007792993,0.0001355116,0.00001305694,0.000001396879,0.00007978973,0.00001127331,0.00001146507,0.9992332,0.00004969737,0.000009729264,0.0004022225],"study_design_scores_gemma":[0.000007453021,0.0001335536,0.01383747,0.000004871471,0.000008941051,0.0006250985,0.0000541159,0.0005248954,0.9831204,0.00003651921,0.001642195,0.000004419484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959695,0.001613063,0.001503775,0.00004015561,0.00001329085,0.00001407989,0.0001746133,0.00004569509,0.0006258589],"genre_scores_gemma":[0.996786,0.000723063,0.0008212002,0.0000214298,0.000005237743,0.00002869103,0.0002945107,0.00001013977,0.001309879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009892818,"threshold_uncertainty_score":0.003309488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455191996702564,"score_gpt":0.23721371607406,"score_spread":0.2226617961070343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}