{"id":"W2046835245","doi":"10.1158/1538-7445.tim2013-ia28","title":"Abstract IA28: Targeting stress-induced molecular chaperones CLU and Hsp27 to inhibit EMT and metastases","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Hsp27; Proteostasis; Clusterin; Epithelial–mesenchymal transition; Cancer research; Biology; Heat shock protein; Vimentin; Cancer; Metastasis; Medicine; Cell biology; Immunology; Apoptosis; Internal medicine; Hsp70; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004754194,0.0001452248,0.0002664992,0.0002374985,0.0001273513,0.00007442375,0.0001006929,0.0000784521,0.0009948058],"category_scores_gemma":[0.0006119277,0.0001261558,0.00003019313,0.0002265394,0.0001872779,0.00009515638,0.0003800849,0.0003529981,0.00008997267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008032638,"about_ca_system_score_gemma":0.0001140525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059042,"about_ca_topic_score_gemma":0.00004998188,"domain_scores_codex":[0.9982562,0.0001076677,0.000207967,0.0004566797,0.000436772,0.0005347094],"domain_scores_gemma":[0.9987231,0.0001719868,0.00003003688,0.0002843457,0.0002877092,0.0005027869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001281039,0.00006553696,0.007689069,0.0004466343,0.00005067737,0.0002415279,0.0004969241,0.000006312212,0.9701462,0.00006139885,0.002633097,0.0180345],"study_design_scores_gemma":[0.003473916,0.001030342,0.4679363,0.001136971,0.0001294058,0.0001123461,0.003551597,0.0001799484,0.5163024,0.0007944766,0.004678117,0.0006741497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909748,0.003609768,0.00001219107,0.003876943,0.00006136076,0.0009131743,0.00004914673,0.00003172139,0.0004708719],"genre_scores_gemma":[0.9981034,0.0002159594,0.0005329422,0.0003760337,0.0001526823,0.0004273445,0.00001519256,0.00003509668,0.000141352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4602473,"threshold_uncertainty_score":0.9999184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07796611160501193,"score_gpt":0.4213044203880965,"score_spread":0.3433383087830846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}