{"id":"W2046863461","doi":"10.1038/ncomms7144","title":"Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Center for AIDS Research, University of Alabama at Birmingham; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; International AIDS Vaccine Initiative; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Trimer; Neutralization; Antibody; Context (archaeology); Glycoprotein; Virology; Chemistry; Neutralizing antibody; Biology; Human immunodeficiency virus (HIV); Virus; Biochemistry; Immunology; Dimer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007373358,0.0002814608,0.0003427204,0.000283485,0.0001515669,0.0005008741,0.0002714754,0.0004542583,0.002370362],"category_scores_gemma":[0.00067156,0.0001843267,0.0002256045,0.0001425395,0.0002796628,0.0003970469,0.0002844751,0.000657351,0.0005622521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847539,"about_ca_system_score_gemma":0.00009858931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780765,"about_ca_topic_score_gemma":0.000234093,"domain_scores_codex":[0.9995362,0.0001595088,0.00002922162,0.00005042228,0.000112908,0.0001118318],"domain_scores_gemma":[0.9993452,0.0003514532,0.0000679104,0.00006082482,0.00009767949,0.00007691573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001789152,0.0001089526,0.001945371,0.00007221226,0.00003316887,0.00002469357,0.00002649825,0.000185279,0.9912867,0.0001759803,0.00008712537,0.005875128],"study_design_scores_gemma":[0.00001638188,0.001424555,0.0158944,0.000007545237,0.00003467864,0.0002622453,0.0000323594,0.0007124885,0.979529,0.0001110548,0.001969028,0.000006295378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855489,0.003443069,0.004783201,0.0001801647,0.00004662325,0.00005681486,0.0001359519,0.00004652092,0.005758768],"genre_scores_gemma":[0.9975254,0.0004869431,0.0006884526,0.000106101,0.00001845303,0.00001246768,0.0001096886,0.000007352529,0.001045096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370362,"threshold_uncertainty_score":0.007929623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02764278506117995,"score_gpt":0.3437917776503948,"score_spread":0.3161489925892148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}