{"id":"W2046863461","doi":"10.1038/ncomms7144","title":"Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Center for AIDS Research, University of Alabama at Birmingham; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; International AIDS Vaccine Initiative; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Trimer; Neutralization; Antibody; Context (archaeology); Glycoprotein; Virology; Chemistry; Neutralizing antibody; Biology; Human immunodeficiency virus (HIV); Virus; Biochemistry; Immunology; Dimer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007598326,0.00009939071,0.0001367663,0.00005428235,0.0004438324,0.0000119682,0.001436762,0.000228628,0.00006463126],"category_scores_gemma":[0.001126037,0.00005123908,0.00006959581,0.0003204429,0.0002029711,0.00004602914,0.0007335008,0.00085688,0.001007761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000585024,"about_ca_system_score_gemma":0.0001134931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002446209,"about_ca_topic_score_gemma":0.001050721,"domain_scores_codex":[0.9988735,0.0004820306,0.0002108369,0.0001530964,0.00006571571,0.0002148369],"domain_scores_gemma":[0.9965997,0.0006810038,0.00006068652,0.002309806,0.0002980402,0.00005070529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001390081,0.00319938,0.06213032,0.00004255321,0.0008556424,0.00000254452,0.05186323,0.00003281044,0.375764,0.016038,0.366005,0.1226765],"study_design_scores_gemma":[0.0008572391,0.0003741413,0.1418252,0.00004227924,0.0000595661,0.00001706838,0.001254928,0.000008200232,0.004480342,0.001571488,0.8493779,0.0001315671],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7678517,0.03219698,0.0002133793,0.1747139,0.0004546267,0.002987373,0.0006648384,0.00009737167,0.02081984],"genre_scores_gemma":[0.9962227,0.0004251155,0.0008800889,0.0003493533,0.00001195661,0.0001084181,0.000604405,0.000007635407,0.001390302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.483373,"threshold_uncertainty_score":0.99977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02764278506117995,"score_gpt":0.3437917776503948,"score_spread":0.3161489925892148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}