{"id":"W2046864912","doi":"10.1046/j.1468-1293.2001.00046.x","title":"MIKADO: a multicentre, open‐label pilot study to evaluate the antiretroviral activity and safety of saquinavir with stavudine and zalcitabine","year":2001,"lang":"en","type":"article","venue":"HIV Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Bristol-Myers Squibb","keywords":"Stavudine; Saquinavir; Medicine; Tolerability; Zalcitabine; Interquartile range; Indinavir; Internal medicine; Lamivudine; Viral load; Gastroenterology; Protease inhibitor (pharmacology); Virology; Pharmacology; Drug holiday; Adverse effect; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002190456,0.001172945,0.001472011,0.000360053,0.0006885539,0.0009762941,0.001076187,0.001055997,0.004522065],"category_scores_gemma":[0.001729525,0.0005966292,0.0009270144,0.0003252916,0.001111852,0.0009943533,0.0006237301,0.001823829,0.0007700135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005610719,"about_ca_system_score_gemma":0.00143194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353939,"about_ca_topic_score_gemma":0.002197766,"domain_scores_codex":[0.9991062,0.0004577498,0.00005767721,0.0001329365,0.0001098443,0.0001356569],"domain_scores_gemma":[0.9981321,0.00035139,0.0003899137,0.0001511452,0.0001464757,0.0008289965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7387133,0.1558547,0.01611442,0.00073173,0.0006826746,0.0003637428,0.0005473293,0.0005690065,0.04615312,0.0001760799,0.0008777441,0.03921619],"study_design_scores_gemma":[0.2393721,0.7320525,0.02497813,0.00002054626,0.0002583619,0.0002619654,0.0001667328,0.0004136804,0.00144884,0.00004162513,0.0009570763,0.00002838032],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976996,0.000276666,0.0001803037,0.00007325378,0.00002815206,0.00099756,0.0002037614,0.00001753971,0.000523188],"genre_scores_gemma":[0.9936802,0.0005445522,0.001387278,0.0002873203,0.0001301222,0.002069056,0.0007157205,0.00001056899,0.001175187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004522065,"threshold_uncertainty_score":0.01512778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05116154166955816,"score_gpt":0.3377636946142292,"score_spread":0.2866021529446711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}