{"id":"W2046864912","doi":"10.1046/j.1468-1293.2001.00046.x","title":"MIKADO: a multicentre, open‐label pilot study to evaluate the antiretroviral activity and safety of saquinavir with stavudine and zalcitabine","year":2001,"lang":"en","type":"article","venue":"HIV Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Bristol-Myers Squibb","keywords":"Stavudine; Saquinavir; Medicine; Tolerability; Zalcitabine; Interquartile range; Indinavir; Internal medicine; Lamivudine; Viral load; Gastroenterology; Protease inhibitor (pharmacology); Virology; Pharmacology; Drug holiday; Adverse effect; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008200052,0.0003128856,0.0007560588,0.00014235,0.0001678629,0.00001665605,0.0001450461,0.00002287645,0.0001174108],"category_scores_gemma":[0.0001720934,0.0001578146,0.0000126829,0.0004790123,0.0002291395,0.0001181923,0.0002272922,0.0001723028,0.00001135099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007162835,"about_ca_system_score_gemma":0.00008348075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004401098,"about_ca_topic_score_gemma":0.0004373383,"domain_scores_codex":[0.998137,0.0001339883,0.0003650991,0.0004591571,0.0005718539,0.0003329049],"domain_scores_gemma":[0.9988362,0.0001858441,0.0001067369,0.0004315948,0.0001530346,0.0002865743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02736605,0.00599048,0.9035828,0.000143931,0.0008882331,0.0004627883,0.009940484,0.000001331091,0.01052805,0.00006780085,0.002806044,0.03822203],"study_design_scores_gemma":[0.05822185,0.0277644,0.9040307,0.0007464008,0.001267237,0.0001851228,0.004511143,0.0003015424,0.0004934324,0.0000116251,0.002195696,0.0002708166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737158,0.0004152733,0.0001066533,0.02121359,0.00005027396,0.003182091,0.00001049723,0.00002872004,0.001277125],"genre_scores_gemma":[0.9905714,0.000308221,0.0007417339,0.000338951,0.00007744637,0.00005624407,0.00001928063,0.00002870002,0.007857976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03795122,"threshold_uncertainty_score":0.6435494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05116154166955816,"score_gpt":0.3377636946142292,"score_spread":0.2866021529446711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}