{"id":"W2046884017","doi":"10.1016/j.cjca.2013.11.013","title":"Congenital Absence of Nitric Oxide Synthase 3 Potentiates Cardiac Dysfunction and Reduces Survival in Doxorubicin- and Trastuzumab-Mediated Cardiomyopathy","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Medicine; Doxorubicin; Cardiotoxicity; Ejection fraction; Nitric oxide synthase; Internal medicine; Cardiomyopathy; Heart failure; Nitric oxide; Trastuzumab; Endocrinology; Pharmacology; Chemotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005458926,0.0001619147,0.0008562395,0.000550874,0.00004983563,0.00001993828,0.00005965354,0.0002008488,0.00001061858],"category_scores_gemma":[0.000338524,0.0001491771,0.0001767866,0.0002456509,0.0003149843,0.0001720191,0.000009094621,0.0003053937,0.000002028856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415563,"about_ca_system_score_gemma":0.0005464189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00362011,"about_ca_topic_score_gemma":0.0002378992,"domain_scores_codex":[0.9987007,0.0001995137,0.0004646071,0.000186242,0.0001563606,0.0002925289],"domain_scores_gemma":[0.9987147,0.0001776357,0.0001883854,0.0001248981,0.0003225757,0.0004717582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001179585,0.000005459422,0.2323845,0.00006054826,0.0005569635,0.0001808809,0.0003548987,0.00009144281,0.7555822,0.00002413005,0.0003505474,0.01029041],"study_design_scores_gemma":[0.00201547,0.0003646493,0.9491001,0.0001163122,0.0002325993,0.001212447,0.002183632,0.00002777464,0.04384828,0.0001596721,0.0005537163,0.0001853256],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994931,0.003274503,0.0001209079,0.0002658354,0.0003615655,0.0002827995,0.00003319101,0.000004942508,0.0007251955],"genre_scores_gemma":[0.998876,0.0006237692,0.00007016741,0.00005236975,0.0003250536,0.00000623488,0.00001229582,0.00001653869,0.00001760832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7167156,"threshold_uncertainty_score":0.6083266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009930674425580136,"score_gpt":0.2111620748009948,"score_spread":0.2012314003754147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}