{"id":"W2046884017","doi":"10.1016/j.cjca.2013.11.013","title":"Congenital Absence of Nitric Oxide Synthase 3 Potentiates Cardiac Dysfunction and Reduces Survival in Doxorubicin- and Trastuzumab-Mediated Cardiomyopathy","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Medicine; Doxorubicin; Cardiotoxicity; Ejection fraction; Nitric oxide synthase; Internal medicine; Cardiomyopathy; Heart failure; Nitric oxide; Trastuzumab; Endocrinology; Pharmacology; Chemotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017419,0.0002125089,0.0002564574,0.0001296632,0.00009846134,0.0001562388,0.0002024002,0.0002595618,0.001005918],"category_scores_gemma":[0.0002982873,0.0001036972,0.000181892,0.0000675181,0.0003880123,0.0001099719,0.0001723211,0.0005806684,0.00009008647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114127,"about_ca_system_score_gemma":0.0002148038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003557659,"about_ca_topic_score_gemma":0.001067675,"domain_scores_codex":[0.9998715,0.00003495608,0.00001106349,0.00002039931,0.00002980622,0.0000322577],"domain_scores_gemma":[0.9997807,0.00005356648,0.00007831203,0.00001514347,0.000008581047,0.00006368369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002347815,0.0002705712,0.005181554,0.00005135025,0.00003991069,0.0006397358,0.00003002246,0.0002508275,0.9824273,0.0002796004,0.0001856417,0.008295683],"study_design_scores_gemma":[0.000950193,0.01307937,0.1879163,0.00008296228,0.0004015849,0.007262636,0.0002684832,0.007024314,0.7767964,0.0005791317,0.005591208,0.0000473839],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988167,0.0003761344,0.0003600171,0.0000755014,0.00002488917,0.000007233878,0.00004121211,0.00001728758,0.0002809844],"genre_scores_gemma":[0.9991484,0.0002300787,0.0002111823,0.00003519231,0.000007738816,0.00000884217,0.00004964587,0.000004518508,0.0003044844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005918,"threshold_uncertainty_score":0.003365159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009930674425580136,"score_gpt":0.2111620748009948,"score_spread":0.2012314003754147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}