{"id":"W2046917877","doi":"10.1016/j.chembiol.2012.08.011","title":"Bacterial Inactivation of the Anticancer Drug Doxorubicin","year":2012,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Doxorubicin; Anthracycline; Biochemistry; Biology; Enzyme; Drug; Streptomyces; Dehydrogenase; Drug discovery; Bacteria; Microbiology; Chemistry; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120874,0.000215844,0.0002069382,0.0001016969,0.00008546321,0.0002203432,0.0001354809,0.0002887394,0.0009142203],"category_scores_gemma":[0.0002462143,0.00008952861,0.0001324228,0.0001069032,0.0001495924,0.0001497761,0.0002016207,0.0004123383,0.0003975036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358723,"about_ca_system_score_gemma":0.0002643379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051416,"about_ca_topic_score_gemma":0.0009656873,"domain_scores_codex":[0.9998059,0.00002861744,0.00001247594,0.00003419537,0.00007103076,0.00004782138],"domain_scores_gemma":[0.999925,0.00001965974,0.00002082591,0.00001107978,0.00001361809,0.000009761427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007008439,0.00001952582,0.0001274401,0.00002138442,0.000002342009,0.00001582131,0.00001040542,0.00005518611,0.9974635,0.0001570919,0.00005043235,0.00200686],"study_design_scores_gemma":[0.00000362372,0.00009471367,0.0005645963,0.000002413099,0.00000198954,0.0000295234,0.000005256602,0.0004389507,0.9981793,0.0000118,0.0006665843,0.000001234082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863473,0.001932781,0.007801982,0.0002953201,0.00008245877,0.0000388333,0.000275664,0.0001121102,0.003113551],"genre_scores_gemma":[0.9936032,0.0008147897,0.001982561,0.0000473708,0.000007345226,0.00001361455,0.0002300079,0.00001574097,0.003285364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051416,"threshold_uncertainty_score":0.003058374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009378682210051927,"score_gpt":0.2599095630387547,"score_spread":0.2505308808287028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}