{"id":"W2046929648","doi":"10.1038/onc.2010.595","title":"The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institut National Du Cancer; Ligue Contre le Cancer; Institute of Cancer Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Neuroblastoma; Receptor tyrosine kinase; Anaplastic lymphoma kinase; Tyrosine kinase; Receptor; Molecular biology; Intracellular; Transfection; Cell culture; Cancer research; Cell biology; Kinase; Biochemistry; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002437915,0.0003893681,0.0002370293,0.0002548122,0.0002071085,0.0004708392,0.0003561754,0.0005477295,0.002973693],"category_scores_gemma":[0.00023012,0.0001835856,0.0004025292,0.0002395055,0.0005840824,0.000320701,0.0002302855,0.0009089754,0.0008556181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004890836,"about_ca_system_score_gemma":0.0006563178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00217342,"about_ca_topic_score_gemma":0.001851368,"domain_scores_codex":[0.9996628,0.00007369609,0.00004372178,0.00003660261,0.000080048,0.0001030914],"domain_scores_gemma":[0.9998084,0.00005954303,0.00004992411,0.00002725525,0.00000840234,0.00004651327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00029272,0.00008343751,0.0002612726,0.00002977111,0.00002337472,0.0002072343,0.00002322507,0.0003466191,0.9962156,0.0008949094,0.0001346822,0.001487053],"study_design_scores_gemma":[0.00004612388,0.0004119254,0.001860481,0.00000852327,0.00003052288,0.0007915618,0.00006809216,0.001607573,0.9926211,0.0001567354,0.002388102,0.000009269567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968101,0.0002898273,0.0006520163,0.0001239221,0.00003526811,0.00001324493,0.0002909517,0.00003779554,0.001746805],"genre_scores_gemma":[0.9974672,0.0001756447,0.0004462044,0.00003330022,0.000004555394,0.00001120626,0.0003411011,0.00001525877,0.001505585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002973693,"threshold_uncertainty_score":0.009948015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05065886588605553,"score_gpt":0.3044367031238484,"score_spread":0.2537778372377929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}