{"id":"W2046951668","doi":"10.1210/me.2008-0232","title":"Liver X Receptor Is a Therapeutic Target for Photoaging and Chronological Skin Aging","year":2008,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Photoaging; Liver X receptor; Biology; HaCaT; Cell biology; Keratinocyte; Inflammation; Signal transduction; Nuclear receptor; Cancer research; Biochemistry; Immunology; In vitro; Transcription factor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005081079,0.0001790872,0.0003622923,0.0001132213,0.0001026892,0.000007666942,0.00007749556,0.00009348767,0.0001952791],"category_scores_gemma":[0.00003825293,0.000151969,0.0001186309,0.00007699215,0.000194778,0.00003304872,0.00006896534,0.0002058112,0.00003221881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002472204,"about_ca_system_score_gemma":0.00003725672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002237853,"about_ca_topic_score_gemma":6.924296e-7,"domain_scores_codex":[0.9988017,0.00005401453,0.0001827832,0.0003926306,0.00009889498,0.0004699672],"domain_scores_gemma":[0.9995189,0.00004676996,0.00004537204,0.0002370859,0.0000480261,0.0001038918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005874067,0.0004657522,0.01714922,0.0002579244,0.0005956855,0.001406877,0.00308888,0.000004934594,0.829844,0.00415582,0.003933499,0.13851],"study_design_scores_gemma":[0.005637242,0.0006387815,0.03141568,0.00003395282,0.000162658,0.00332383,0.00009968981,0.0004984387,0.3165435,0.0004318246,0.6408717,0.0003426936],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979703,0.009420548,0.006535947,0.003086481,0.000211773,0.0004717783,0.000007229216,0.00009086927,0.0004723466],"genre_scores_gemma":[0.9848739,0.0008740167,0.006553905,0.006785527,0.0002103701,0.00008827035,0.00001626679,0.00003020777,0.0005675294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6369382,"threshold_uncertainty_score":0.6197117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252825135238656,"score_gpt":0.2716768761207128,"score_spread":0.2463943625968472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}