{"id":"W2046984143","doi":"10.1016/s1470-2045(10)70204-7","title":"Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial","year":2010,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":447,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Centre Hospitalier Universitaire Sainte-Justine; McMaster University","funders":"National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Miami","keywords":"Dexrazoxane; Medicine; Doxorubicin; Anthracycline; Chemotherapy; Internal medicine; Surgery; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008174249,0.0002398331,0.001487772,0.0001247247,0.00005656205,0.00000718918,0.0001892762,0.0002956007,0.00004592775],"category_scores_gemma":[0.0001899935,0.0001498039,0.0001977954,0.0003251512,0.000275046,0.00004762771,0.00004165079,0.0007052539,0.000002658564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003085668,"about_ca_system_score_gemma":0.0005961477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017003,"about_ca_topic_score_gemma":0.001469446,"domain_scores_codex":[0.998183,0.0003023048,0.0004976246,0.0003383992,0.0003311002,0.0003475994],"domain_scores_gemma":[0.9984013,0.0003087017,0.0004843198,0.0005574789,0.0001683377,0.00007990545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2103344,0.0005441005,0.2791557,0.00007067649,0.001790747,0.00008470233,0.0007252486,0.00004842318,0.5042608,0.0001492327,0.00001116896,0.002824692],"study_design_scores_gemma":[0.3523037,0.002448539,0.4386044,0.00009858447,0.0009102998,0.0002453845,0.00004075462,0.00004414552,0.2051388,0.00005550889,0.000004179444,0.0001057484],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993719,0.00003833996,0.0001489868,0.000251897,0.0002321292,0.004749164,0.00003767692,0.00004055677,0.0007822826],"genre_scores_gemma":[0.9983473,0.0001660542,0.000607217,0.00008375961,0.0003957594,0.000267743,0.0000370278,0.00003052762,0.00006463559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2991221,"threshold_uncertainty_score":0.6108826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014617022172221,"score_gpt":0.2953553311395192,"score_spread":0.285209160917797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}