{"id":"W2047004272","doi":"10.1161/hy0202.103000","title":"Proprotein Convertase PC5 Regulation by PDGF-BB Involves PI3-Kinase/p70 <sup>s6</sup> -Kinase Activation in Vascular Smooth Muscle Cells","year":2002,"lang":"en","type":"article","venue":"Hypertension","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"","keywords":"Furin; Wortmannin; Platelet-derived growth factor receptor; Biology; Vascular smooth muscle; Proprotein convertase; Endocrinology; Angiotensin II; Internal medicine; P70-S6 Kinase 1; Protein kinase A; Platelet-derived growth factor; Cell biology; Kinase; Molecular biology; Phosphorylation; Protein kinase B; Growth factor; Biochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001275783,0.0003796534,0.0002159735,0.0002549172,0.0002242448,0.0004829602,0.00008610208,0.0002196589,0.0007587554],"category_scores_gemma":[0.00009196354,0.0001379861,0.0003957511,0.0001786641,0.0001865348,0.0001964408,0.000211395,0.0004370283,0.0003682647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591921,"about_ca_system_score_gemma":0.0002181256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700939,"about_ca_topic_score_gemma":0.001568146,"domain_scores_codex":[0.9998468,0.00002650985,0.00001374058,0.00002781008,0.00004043885,0.00004476361],"domain_scores_gemma":[0.9999075,0.00001150609,0.00002373625,0.000007305379,0.00001973717,0.00003019702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989826,0.00001182364,0.0003503695,0.0000458948,0.000006135417,0.00009363664,0.00001968495,0.00003285535,0.9979841,0.00006975068,0.00002824947,0.001158425],"study_design_scores_gemma":[0.00001585005,0.0001842012,0.03026092,0.00001228364,0.00003010957,0.0003023475,0.00008090756,0.001133845,0.9648783,0.00007948225,0.003015062,0.000006749686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820048,0.01144466,0.003720527,0.0001860924,0.00005431809,0.00002722324,0.0004053221,0.00006379966,0.002093329],"genre_scores_gemma":[0.9916891,0.003614296,0.001976335,0.00006133343,0.00002360521,0.00002959158,0.0006077734,0.0000084155,0.001989529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700939,"threshold_uncertainty_score":0.003382087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341357900951683,"score_gpt":0.1880497925630381,"score_spread":0.1746362135535212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}