{"id":"W2047004272","doi":"10.1161/hy0202.103000","title":"Proprotein Convertase PC5 Regulation by PDGF-BB Involves PI3-Kinase/p70 <sup>s6</sup> -Kinase Activation in Vascular Smooth Muscle Cells","year":2002,"lang":"en","type":"article","venue":"Hypertension","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"","keywords":"Furin; Wortmannin; Platelet-derived growth factor receptor; Biology; Vascular smooth muscle; Proprotein convertase; Endocrinology; Angiotensin II; Internal medicine; P70-S6 Kinase 1; Protein kinase A; Platelet-derived growth factor; Cell biology; Kinase; Molecular biology; Phosphorylation; Protein kinase B; Growth factor; Biochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002797515,0.0002973868,0.0002580834,0.0001094394,0.0001422496,0.00003788443,0.0001565025,0.0003702872,0.0001261766],"category_scores_gemma":[0.0001127412,0.000281949,0.0001275433,0.0001715226,0.00005887476,0.000047196,0.00009479894,0.0001798041,0.00007530354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004855387,"about_ca_system_score_gemma":0.0000314869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001762973,"about_ca_topic_score_gemma":0.00001157124,"domain_scores_codex":[0.9981261,0.0001894679,0.0003487144,0.0006534117,0.0002998612,0.0003824733],"domain_scores_gemma":[0.9990054,0.00001356665,0.0001291971,0.0005856825,0.0001324199,0.0001337746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005699265,0.0002909341,0.00002326661,0.0000376993,0.00001422432,0.00001117881,0.00005981577,0.0001126866,0.9777117,0.00002571251,0.01377532,0.007880455],"study_design_scores_gemma":[0.001343469,0.0003127676,0.0001745654,0.0001084711,0.00002248702,0.000002304552,0.00008619018,0.01179053,0.9537317,0.0001225262,0.03192451,0.0003804434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955157,0.001316618,0.001669727,0.0002796405,0.0001022276,0.0008520741,0.00001982606,0.00004531984,0.0001988723],"genre_scores_gemma":[0.9970404,0.0002473984,0.0005652676,0.0009970665,0.0002035287,0.00009254526,0.0004733685,0.00005214148,0.0003282684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02397998,"threshold_uncertainty_score":0.9999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341357900951683,"score_gpt":0.1880497925630381,"score_spread":0.1746362135535212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}