{"id":"W2047008186","doi":"10.1038/sj.onc.1208441","title":"Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Bone marrow; Haematopoiesis; Cancer research; Leukemia; MAPK/ERK pathway; Systemic mastocytosis; Mast cell; Immunology; Molecular biology; Cell biology; Kinase; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003546493,0.0004663799,0.0004256678,0.0005341575,0.0002957148,0.0005953826,0.0003623798,0.000497158,0.001640435],"category_scores_gemma":[0.0002780946,0.000365133,0.0003489258,0.0002967997,0.0004878383,0.000309461,0.0003370821,0.001280738,0.000660528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004904388,"about_ca_system_score_gemma":0.0004274273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007493986,"about_ca_topic_score_gemma":0.001255302,"domain_scores_codex":[0.9995307,0.00008631773,0.00005719417,0.00005510306,0.0001299437,0.0001407788],"domain_scores_gemma":[0.9992575,0.0002289112,0.0001638968,0.0001025035,0.00003889878,0.0002081481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001952119,0.00004950929,0.0001795896,0.00001246023,0.000003262687,0.00007084896,0.00001303736,0.00003969024,0.9989153,0.0001717288,0.00002217584,0.0003272432],"study_design_scores_gemma":[0.00004703916,0.000522125,0.004477226,0.000006279602,0.00002131564,0.0005542644,0.00004486188,0.001098573,0.9915604,0.00008056976,0.001582907,0.000004448872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995596,0.0008827744,0.001856894,0.0001078705,0.00003463145,0.00004686694,0.0003899031,0.0001124686,0.0009726247],"genre_scores_gemma":[0.9963899,0.0002998009,0.001227533,0.00002684418,0.00001448899,0.0000350267,0.0006121996,0.00002922753,0.001364896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640435,"threshold_uncertainty_score":0.0054878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642641248573969,"score_gpt":0.229580254037712,"score_spread":0.2131538415519723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}