{"id":"W2047045426","doi":"10.1016/j.bmcl.2009.09.068","title":"Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Agonist; Benzamide; Piperidine; Amide; Stereochemistry; Metabolic stability; Carboxamide; Selectivity; Delta; δ-opioid receptor; In vitro; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003085377,0.0004387134,0.0003024698,0.0002155678,0.0001402696,0.0003203459,0.000503385,0.0002638532,0.001805375],"category_scores_gemma":[0.0002768663,0.0002086592,0.000204313,0.0001251256,0.0002088265,0.0003229232,0.0002956483,0.0004940748,0.0006572676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489857,"about_ca_system_score_gemma":0.0003449543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005863201,"about_ca_topic_score_gemma":0.001229633,"domain_scores_codex":[0.9999099,0.00001341555,0.00001067871,0.00001804403,0.00001666681,0.00003123299],"domain_scores_gemma":[0.9998926,0.00001614933,0.00002400373,0.00001280265,0.00002416509,0.00003027965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005372248,0.0001247681,0.0003311485,0.0001547113,0.00002140966,0.0003933525,0.00009056734,0.0006857541,0.9696667,0.001355442,0.0003126709,0.02632626],"study_design_scores_gemma":[0.000228283,0.003293363,0.001252833,0.00002606495,0.00008074466,0.0008350551,0.00005501216,0.001174493,0.9785194,0.0002505831,0.0142562,0.00002796612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646521,0.007500465,0.01857737,0.0003606468,0.0001222119,0.000158119,0.0006687616,0.0002049189,0.007755363],"genre_scores_gemma":[0.9812227,0.004900707,0.007664277,0.0001453806,0.00004766734,0.00007934218,0.0006517668,0.00003710248,0.005250999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805375,"threshold_uncertainty_score":0.00603956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684009198512015,"score_gpt":0.2278603277843281,"score_spread":0.2110202357992079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}