{"id":"W2047098332","doi":"10.1139/o2012-030","title":"Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells","year":2012,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Olympus","keywords":"Gambogic acid; Apoptosis; Cancer research; In vivo; Cytochrome c; Metastasis; Caspase; Viability assay; Biology; In vitro; Protein kinase B; Chemistry; Programmed cell death; Cancer; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690877,0.0001886965,0.0002348661,0.00001259566,0.0001947876,0.00001817771,0.0001383283,0.0001262331,0.00005572674],"category_scores_gemma":[0.000009399751,0.00008679459,0.00003192472,0.0001456492,0.0001768294,0.00004446522,0.0001681485,0.0001466589,0.000005947981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001760896,"about_ca_system_score_gemma":0.000003701732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005696289,"about_ca_topic_score_gemma":0.00003533287,"domain_scores_codex":[0.9989161,0.00009295385,0.0001828307,0.0003484495,0.00005001412,0.0004096397],"domain_scores_gemma":[0.999631,0.00007649483,0.00006376576,0.00004731116,0.00002793695,0.0001534176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004963389,0.0001837667,0.01157438,0.00003447504,0.00001100167,0.000001918825,0.00005198878,1.676005e-8,0.9869829,0.00001988662,0.0002992705,0.0007906955],"study_design_scores_gemma":[0.0004792989,0.0001235908,0.02828428,0.000008854899,0.00002878706,0.00001320328,0.0002123584,7.620727e-7,0.9685653,0.0001749527,0.001864488,0.000244146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937127,0.004563855,2.788258e-7,0.0007453474,0.0001002919,0.0001625869,0.00008782702,0.00002003881,0.0006070498],"genre_scores_gemma":[0.9989523,0.00007565357,0.0001471568,0.0002004505,0.000184393,0.00002521789,0.00004696714,0.000001126694,0.0003667259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01841769,"threshold_uncertainty_score":0.353938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559150865254452,"score_gpt":0.2427304966947569,"score_spread":0.2271389880422124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}