{"id":"W2047098628","doi":"10.1038/nprot.2008.55","title":"Production of neurons, astrocytes and oligodendrocytes from mammalian CNS stem cells","year":2008,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Neurosphere; Neural stem cell; Cell biology; Stem cell; Biology; Cell culture; Epidermal growth factor; Neuroscience; Adult stem cell; Endothelial stem cell; In vitro; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007553802,0.0002408513,0.0002926283,0.0001051583,0.000194575,0.00003343439,0.0002816224,0.0001744502,0.0000237658],"category_scores_gemma":[0.0001550191,0.0002122798,0.00006840131,0.0002522493,0.0001430873,0.0001973894,0.0001219052,0.0004683017,0.00002742553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001226015,"about_ca_system_score_gemma":0.00004604686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005325285,"about_ca_topic_score_gemma":0.000002201581,"domain_scores_codex":[0.9980288,0.0002014175,0.0003113077,0.0007285469,0.0004472613,0.0002826505],"domain_scores_gemma":[0.9990355,0.0002114878,0.0002138783,0.0003707226,0.00005315333,0.0001153082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531179,0.0001149928,0.0005469777,0.00005283255,0.000002529108,0.00006027615,0.00007308813,0.00001191861,0.997889,0.0004101159,0.0001590983,0.0005260006],"study_design_scores_gemma":[0.0004130804,0.0003271326,0.001480556,0.00005354453,0.00001003874,0.0001164749,0.000008555224,0.00004316706,0.9935175,0.00003809766,0.00382644,0.0001654401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789049,0.00003866871,0.00005140304,0.00008136205,0.0003355492,0.02035679,0.00004510483,0.0001010933,0.00008514561],"genre_scores_gemma":[0.9918578,0.00003208673,0.0004421819,0.000306127,0.0001563153,0.006677436,8.811928e-7,0.00004027309,0.0004868794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01367935,"threshold_uncertainty_score":0.8656518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03528432032146049,"score_gpt":0.271721911217771,"score_spread":0.2364375908963104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}