{"id":"W2047131453","doi":"10.1016/j.cbpc.2008.01.001","title":"20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain","year":2008,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Veratridine; Protopanaxadiol; Chemistry; Sodium channel; Depolarization; Sodium channel blocker; Biophysics; Glutamate receptor; Sodium; Inhibitory postsynaptic potential; Biochemistry; Pharmacology; Ginsenoside; Endocrinology; Ginseng; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001763337,0.0004197169,0.0005911874,0.00005863122,0.0005071224,0.00001728827,0.0001974697,0.0005927045,0.00005223159],"category_scores_gemma":[0.00006427499,0.000334963,0.00007054616,0.0001630781,0.001896,0.00001790995,0.0002035949,0.0005959045,0.000006068533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002223132,"about_ca_system_score_gemma":0.000062386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004926007,"about_ca_topic_score_gemma":0.00002577554,"domain_scores_codex":[0.997296,0.0007860977,0.0004247118,0.00096198,0.00006238605,0.0004688452],"domain_scores_gemma":[0.99887,0.0003684628,0.0002266117,0.0002634765,0.00007508499,0.0001963309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001536665,0.0002338792,0.0007473397,0.00002745596,0.0002047479,0.00002152099,0.0002527414,0.0001148742,0.9959555,0.00003525562,0.0007908135,0.00007922874],"study_design_scores_gemma":[0.004509805,0.0006461919,0.01748752,0.00001662009,0.00009765277,0.0002386965,0.0001207403,0.002853323,0.9718957,0.0002672255,0.001432305,0.0004342172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937531,0.001712154,0.00046045,0.002620103,0.0001522833,0.001092703,0.0001271637,0.00003255181,0.00004951187],"genre_scores_gemma":[0.9945448,0.0005950381,0.00003237139,0.003202815,0.0002464437,0.0007346604,0.0005130288,0.00001992646,0.0001109179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02405977,"threshold_uncertainty_score":0.9999102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180522784154915,"score_gpt":0.2772971666928748,"score_spread":0.2554919388513257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}