{"id":"W2047131453","doi":"10.1016/j.cbpc.2008.01.001","title":"20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain","year":2008,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Veratridine; Protopanaxadiol; Chemistry; Sodium channel; Depolarization; Sodium channel blocker; Biophysics; Glutamate receptor; Sodium; Inhibitory postsynaptic potential; Biochemistry; Pharmacology; Ginsenoside; Endocrinology; Ginseng; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001782849,0.0006204229,0.000555083,0.0003677383,0.0003393349,0.0003225924,0.0002698283,0.0003563425,0.002308087],"category_scores_gemma":[0.0002510534,0.0002731046,0.0004412626,0.0003239871,0.0003851027,0.0005461377,0.0002618888,0.0005498444,0.0007110796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577991,"about_ca_system_score_gemma":0.0004335266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302498,"about_ca_topic_score_gemma":0.001913634,"domain_scores_codex":[0.9999,0.0000149992,0.000009591557,0.00001363404,0.00001549976,0.00004629718],"domain_scores_gemma":[0.9999095,0.00002577145,0.0000115734,0.00001144444,0.000008328132,0.00003334037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001992158,0.00006743635,0.000207219,0.00007500974,0.00003517957,0.0002288411,0.00004762547,0.00007690999,0.9952695,0.0001332913,0.00008352522,0.00178323],"study_design_scores_gemma":[0.0001329846,0.001396505,0.007400287,0.000006710523,0.00006564599,0.0007293944,0.00008610917,0.0004352971,0.9878947,0.0001892911,0.001652684,0.00001038776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939771,0.002361468,0.0006440138,0.0001106197,0.00005470046,0.00002887467,0.0003092925,0.00005114179,0.002462832],"genre_scores_gemma":[0.9857746,0.003829682,0.001452827,0.0001647736,0.0000820874,0.00004990309,0.001760463,0.00004698669,0.006838583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308087,"threshold_uncertainty_score":0.007721364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02180522784154915,"score_gpt":0.2772971666928748,"score_spread":0.2554919388513257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}