{"id":"W2047181533","doi":"10.1016/j.ccr.2010.11.013","title":"Cooperative Epigenetic Modulation by Cancer Amplicon Genes","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Demethylase; Biology; Histone; Epigenetics; Chromatin; Epigenome; Cancer research; Histone H3; Amplicon; Gene; PRC2; Molecular biology; Genetics; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00002196095,0.0001209831,0.0001608709,0.00001422612,0.00005907064,0.00001574983,0.00003730926,0.00006971459,0.001921539],"category_scores_gemma":[0.000003205358,0.00009372061,0.00004350167,0.00005885568,0.00003575045,0.00004210518,0.00001202083,0.0000590802,0.00004531176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828493,"about_ca_system_score_gemma":0.0001471669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003088296,"about_ca_topic_score_gemma":0.001262823,"domain_scores_codex":[0.9993764,0.000009382509,0.000115744,0.0002290756,0.0001090161,0.000160442],"domain_scores_gemma":[0.9995494,0.00001833149,0.00004447938,0.0001846805,0.00008930285,0.0001137593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005625556,0.0004163801,0.2231122,0.0000540041,0.00009827594,0.000009670707,0.0003556693,0.0001806747,0.6402693,0.00009727678,0.0150826,0.1202677],"study_design_scores_gemma":[0.002197822,0.0001331618,0.1363398,0.00003352198,0.0001406512,0.000002771099,0.00003467319,0.0005723655,0.767217,0.00001944209,0.09313947,0.0001692524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828543,0.01247116,0.00003011167,0.0007043217,0.0004984268,0.0003405748,0.00005915838,0.00002842232,0.003013544],"genre_scores_gemma":[0.9917172,0.003963405,0.00009481478,0.0006152079,0.0002765548,0.000398238,0.00004972076,0.00001845598,0.002866425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1269478,"threshold_uncertainty_score":0.9989908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235093467640409,"score_gpt":0.286825638688521,"score_spread":0.2744747040121169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}