{"id":"W2047181533","doi":"10.1016/j.ccr.2010.11.013","title":"Cooperative Epigenetic Modulation by Cancer Amplicon Genes","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Demethylase; Biology; Histone; Epigenetics; Chromatin; Epigenome; Cancer research; Histone H3; Amplicon; Gene; PRC2; Molecular biology; Genetics; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004090731,0.000269278,0.0002501601,0.0005749467,0.0002992275,0.0006848171,0.0003116121,0.0003637435,0.005211217],"category_scores_gemma":[0.0007668633,0.0002625493,0.0002927355,0.0002873805,0.0002879743,0.0004201971,0.0007566434,0.0005158461,0.0005738922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004332695,"about_ca_system_score_gemma":0.0002532486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004773335,"about_ca_topic_score_gemma":0.001045138,"domain_scores_codex":[0.9995383,0.00008072251,0.00002105937,0.0001227949,0.0001313177,0.0001057695],"domain_scores_gemma":[0.9996018,0.0001316493,0.00007781009,0.00007828519,0.00006399916,0.00004646261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004122959,0.0000852463,0.01381893,0.00006410412,0.00004635539,0.0003130011,0.0002006984,0.0004340694,0.9546843,0.004062592,0.000399356,0.02547891],"study_design_scores_gemma":[0.00006056513,0.0005070549,0.09933811,0.00002134304,0.0001266487,0.001484126,0.0002715231,0.003823256,0.8830028,0.00213927,0.00921015,0.00001521084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752889,0.004353242,0.007898073,0.0005060468,0.00008520365,0.00004554107,0.0003452776,0.0001901186,0.0112877],"genre_scores_gemma":[0.9936535,0.0004827816,0.00129903,0.00009485097,0.00001616074,0.00002006897,0.0001609309,0.00002412492,0.004248512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005211217,"threshold_uncertainty_score":0.01743323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235093467640409,"score_gpt":0.286825638688521,"score_spread":0.2744747040121169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}