{"id":"W2047264823","doi":"10.1371/journal.pgen.1000157","title":"Selective Constraints in Experimentally Defined Primate Regulatory Regions","year":2008,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; DNA binding site; Genetics; Computational biology; Chromatin immunoprecipitation; Gene; Regulatory sequence; ChIP-sequencing; Conserved sequence; Transcription factor; Promoter; Gene expression; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207941,0.0003555481,0.0006625102,0.001341891,0.0007685247,0.0006802331,0.0004514412,0.0004775305,0.002574319],"category_scores_gemma":[0.004487558,0.0002962787,0.0006430813,0.001644737,0.0009049411,0.0003202699,0.0007337767,0.0006251074,0.0004869034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005647611,"about_ca_system_score_gemma":0.0004376651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003061137,"about_ca_topic_score_gemma":0.006793648,"domain_scores_codex":[0.9984514,0.0004548354,0.0001103445,0.0006508047,0.0002497568,0.00008292542],"domain_scores_gemma":[0.9976484,0.001280666,0.0004814175,0.0003720717,0.0001331021,0.00008434283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001243963,0.0001487557,0.1633086,0.00152593,0.000745096,0.0009138646,0.00193284,0.02437578,0.7420933,0.008487138,0.001530655,0.05369416],"study_design_scores_gemma":[0.0001456148,0.0005647417,0.711657,0.0003745888,0.0006465818,0.005988371,0.001278523,0.073865,0.1433964,0.02141601,0.04049551,0.0001717371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821433,0.0025281,0.008729741,0.00007558145,0.000009041582,0.0000200414,0.002796646,0.0001490807,0.003548515],"genre_scores_gemma":[0.9768266,0.0006683786,0.01139783,0.0001872866,0.00001924445,0.00008127638,0.01040544,0.0001033081,0.0003107061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003061137,"threshold_uncertainty_score":0.008611977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320236160935303,"score_gpt":0.2276279357170716,"score_spread":0.2144255741077186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}