{"id":"W2047288355","doi":"10.1074/jbc.m705672200","title":"Activation of the SspA Serine Protease Zymogen of Staphylococcus aureus Proceeds through Unique Variations of a Trypsinogen-like Mechanism and Is Dependent on Both Autocatalytic and Metalloprotease-specific Processing","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Zymogen; Endopeptidase; Protein precursor; Active site; Chemistry; Biochemistry; Proteolysis; Cleavage (geology); Serine; Protease; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002264551,0.000142527,0.000242904,0.00001917077,0.00004228829,0.000007954696,0.000146779,0.0002384931,0.00001118974],"category_scores_gemma":[0.0001097505,0.00008631507,0.00008374875,0.0001188359,0.0001543614,0.0000126052,0.00007863681,0.000157452,2.432702e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001646199,"about_ca_system_score_gemma":0.00006630085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003153533,"about_ca_topic_score_gemma":1.73161e-7,"domain_scores_codex":[0.9990062,0.00002333571,0.0004980118,0.0001804681,0.000175055,0.0001169374],"domain_scores_gemma":[0.9988137,0.00001625797,0.0007401468,0.0001291013,0.0002410928,0.00005965316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004076494,0.00009665978,0.0006847972,0.0001892826,0.00004984377,8.342485e-7,0.00006234835,0.0000026006,0.9977542,0.00006380797,0.00000535962,0.000682646],"study_design_scores_gemma":[0.0004300864,0.0003064408,0.007911737,0.00008863801,0.00002779405,0.00003275902,0.00007064284,0.00001838373,0.9899117,0.001015803,0.00009223921,0.00009377049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965943,0.0002862421,0.002681822,0.0001193931,0.00001641868,0.000229015,0.00002656924,0.000002413131,0.00004386323],"genre_scores_gemma":[0.9985486,0.0001148775,0.001152544,0.00005895633,0.0000714288,0.00000391115,0.00001874769,0.000006806021,0.00002410016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007842465,"threshold_uncertainty_score":0.3519826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01755927482999252,"score_gpt":0.239257810995396,"score_spread":0.2216985361654035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}