{"id":"W2047312768","doi":"10.1016/j.ab.2005.10.001","title":"Multiplexed DNA sequencing-by-synthesis","year":2005,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Human Genome Research Institute","keywords":"Nucleotide; DNA; DNA polymerase; Polymerase; Quenching (fluorescence); Chemistry; DNA nanoball sequencing; Fluorescein; Single molecule real time sequencing; Deoxyribonucleoside; Molecular biology; Combinatorial chemistry; DNA sequencing; Biochemistry; Biology; Fluorescence; Gene; Base sequence; Genomic library; DNA sequencer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623409,0.0002593705,0.0002443954,0.00003295013,0.00009407312,0.00003380247,0.0002591114,0.0003183099,0.00003290297],"category_scores_gemma":[0.0004046629,0.0002330097,0.0002279594,0.0001607842,0.0002150901,0.000004694575,0.0001066829,0.0001395469,0.00002867073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007475145,"about_ca_system_score_gemma":0.00006702846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006863266,"about_ca_topic_score_gemma":0.000005176881,"domain_scores_codex":[0.9984913,0.00002819793,0.0003018324,0.0005957704,0.0002045712,0.0003783446],"domain_scores_gemma":[0.9990248,0.00003001033,0.0000857351,0.0005651963,0.0001012122,0.000193055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003035645,0.00006331913,0.0001765752,0.000008831988,0.00008205665,0.000002669793,0.000002017696,0.000003446132,0.9728897,0.00001021657,0.02178682,0.00494396],"study_design_scores_gemma":[0.0001401887,0.00003558433,0.00001340382,0.00001382386,0.00006863752,0.00001760691,0.00002979865,0.0005876163,0.9630462,0.00001687504,0.03571083,0.0003194377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907171,0.0003827865,0.0009870689,0.001335672,0.00002192693,0.00008996818,0.00008690107,0.0001354218,0.006243161],"genre_scores_gemma":[0.9888238,0.0001035678,0.006214702,0.0007312691,0.0004043456,0.00001158908,0.0001837143,0.00002672165,0.003500272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01392401,"threshold_uncertainty_score":0.950186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011714308553438,"score_gpt":0.264107987208437,"score_spread":0.2539908441229026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}