{"id":"W2047312768","doi":"10.1016/j.ab.2005.10.001","title":"Multiplexed DNA sequencing-by-synthesis","year":2005,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Human Genome Research Institute","keywords":"Nucleotide; DNA; DNA polymerase; Polymerase; Quenching (fluorescence); Chemistry; DNA nanoball sequencing; Fluorescein; Single molecule real time sequencing; Deoxyribonucleoside; Molecular biology; Combinatorial chemistry; DNA sequencing; Biochemistry; Biology; Fluorescence; Gene; Base sequence; Genomic library; DNA sequencer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003124594,0.003401678,0.002729171,0.002380682,0.0009716006,0.001246887,0.00215743,0.0018354,0.00942392],"category_scores_gemma":[0.002458895,0.002334115,0.001535375,0.001055157,0.001253493,0.001247888,0.002538374,0.003341641,0.007204779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008939829,"about_ca_system_score_gemma":0.001551181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004156164,"about_ca_topic_score_gemma":0.001580321,"domain_scores_codex":[0.9944884,0.001249383,0.0003001791,0.002134745,0.001221683,0.0006056027],"domain_scores_gemma":[0.9985507,0.000462321,0.0001862392,0.0003413914,0.0002624888,0.0001968292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000324594,0.0001450456,0.0001821945,0.000337046,0.00009463021,0.00009982254,0.0001497898,0.0008995727,0.9583084,0.003034709,0.002103233,0.03432103],"study_design_scores_gemma":[0.00006072051,0.0002671277,0.0001485778,0.00001983419,0.0000471893,0.0001234239,0.0000125588,0.006322726,0.9780865,0.0006750238,0.01419306,0.00004310803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03129182,0.0009963086,0.9499015,0.0002280956,0.0004435428,0.002224856,0.001329353,0.008511817,0.005072529],"genre_scores_gemma":[0.08633709,0.0008893482,0.8878213,0.0006755269,0.0001150385,0.003758253,0.00248705,0.0008583613,0.01705801],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00942392,"threshold_uncertainty_score":0.03152615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011714308553438,"score_gpt":0.264107987208437,"score_spread":0.2539908441229026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}