{"id":"W2047330433","doi":"10.2165/00063030-200923020-00002","title":"Current Status and Challenges Associated with Targeting mTOR for Cancer Therapy","year":2009,"lang":"en","type":"review","venue":"BioDrugs","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Howard Hughes Medical Institute","keywords":"PI3K/AKT/mTOR pathway; Sirolimus; Protein kinase B; Cancer; Cancer research; RPTOR; Signal transduction; Pharmacology; Biology; Medicine; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002578892,0.0004559327,0.0007832593,0.00005498421,0.00008761962,0.00003673463,0.0001976365,0.0003645263,0.000009814229],"category_scores_gemma":[0.00007406147,0.0003366555,0.0002089806,0.00008064106,0.00007242015,0.000002904204,0.000044131,0.0001723475,0.000001291355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009652038,"about_ca_system_score_gemma":0.0005142633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001223639,"about_ca_topic_score_gemma":0.00002863247,"domain_scores_codex":[0.9982833,0.0001043831,0.000310445,0.0006715255,0.0001550226,0.0004753436],"domain_scores_gemma":[0.9990401,0.00005838045,0.000378115,0.0002694622,0.0001359218,0.0001179936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003382154,0.00004905296,0.00001541248,0.001670794,0.0003090326,5.279077e-7,0.00003708524,4.910814e-7,0.0000988918,0.000008640372,0.001948787,0.9958274],"study_design_scores_gemma":[0.0005332842,0.0003693032,0.00001629148,0.003112344,0.0001897517,0.000001254594,0.00001050944,0.000001038307,0.0002327621,0.00000790609,0.995052,0.0004735218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003257045,0.9979364,0.00001713253,0.00005829522,0.0003571136,0.0008175416,0.0004147885,0.00002656082,0.00004643917],"genre_scores_gemma":[0.00009517086,0.9975908,0.0001404673,0.00005486176,0.00081819,0.0004235401,0.000687913,0.00007980369,0.0001091965],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9953539,"threshold_uncertainty_score":0.9999086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07859009767915429,"score_gpt":0.3535119843236535,"score_spread":0.2749218866444992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}