{"id":"W2047363194","doi":"10.1152/ajpcell.00160.2011","title":"Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"ATF6; Unfolded protein response; Endoplasmic reticulum; Gene knockdown; Activating transcription factor; Cell biology; XBP1; Protein kinase A; Biology; Protein kinase R; EIF-2 kinase; ATF4; Kinase; Chemistry; Apoptosis; Biochemistry; Cyclin-dependent kinase 2; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001495827,0.0005018007,0.0004115449,0.0001636128,0.0001597872,0.0004863483,0.0002547712,0.0002166826,0.002203118],"category_scores_gemma":[0.0001111857,0.0001718132,0.0003543555,0.0002404919,0.0001776369,0.0003324246,0.00025693,0.0008429138,0.001899029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803431,"about_ca_system_score_gemma":0.0001443212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002560763,"about_ca_topic_score_gemma":0.0002720667,"domain_scores_codex":[0.9998481,0.00001136599,0.00001984005,0.00004171183,0.00004794999,0.00003105648],"domain_scores_gemma":[0.999795,0.00002094233,0.00005007513,0.00004565327,0.0000334225,0.00005493145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008867174,0.00002308453,0.0002398681,0.00003374419,0.000005023725,0.00005970475,0.00001014192,0.00001304117,0.9979584,0.00004630419,0.00007593043,0.001446114],"study_design_scores_gemma":[0.00002324074,0.0003112912,0.01607698,0.00002079549,0.00002370672,0.0009292883,0.00006117224,0.0003456219,0.9732658,0.0001434039,0.008789382,0.000009421916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971588,0.006276035,0.01113579,0.0003175728,0.000198613,0.0000675297,0.003154227,0.0005365131,0.006725712],"genre_scores_gemma":[0.9726709,0.004192751,0.005969601,0.0002621741,0.00005340297,0.0001091829,0.006473905,0.0001126649,0.01015533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203118,"threshold_uncertainty_score":0.007370114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112447795312411,"score_gpt":0.2467883609110242,"score_spread":0.2356638829579001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}