{"id":"W2047367625","doi":"10.1016/j.stem.2010.09.010","title":"Benefits of Utilizing Gene-Modified iPSCs for Clinical Applications","year":2010,"lang":"en","type":"letter","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"","keywords":"Induced pluripotent stem cell; Reprogramming; Transgene; Biology; Genetic enhancement; Context (archaeology); Cancer research; Bioinformatics; Gene; Computational biology; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001637677,0.0004815737,0.0005064611,0.0001864884,0.0003706822,0.000997772,0.0005661845,0.004386127,0.003060682],"category_scores_gemma":[0.003135073,0.0001963762,0.0005939982,0.0001668394,0.001485123,0.001014766,0.0005423459,0.005384583,0.001821386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004001334,"about_ca_system_score_gemma":0.0003484474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001867544,"about_ca_topic_score_gemma":0.0004726374,"domain_scores_codex":[0.9993796,0.000235423,0.00007209122,0.00006456368,0.0002032968,0.00004505286],"domain_scores_gemma":[0.997804,0.001743794,0.00007751009,0.0001324846,0.0001734761,0.0000687685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002531831,0.0008492877,0.006874624,0.001723412,0.0002896257,0.03925706,0.0005005868,0.002733851,0.163892,0.05962814,0.3059168,0.4158028],"study_design_scores_gemma":[0.0008536737,0.001336079,0.005637697,0.000269041,0.0002966981,0.06389146,0.0003645209,0.004618648,0.09782737,0.04877101,0.7759956,0.0001381492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04862826,0.06169419,0.03415948,0.7765446,0.02559206,0.0001650295,0.0003202631,0.0005482674,0.0523479],"genre_scores_gemma":[0.4843362,0.06850941,0.04384255,0.2789081,0.08417338,0.0004924021,0.0003998809,0.0002863559,0.03905176],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.004386127,"threshold_uncertainty_score":0.01023895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06140357998873566,"score_gpt":0.3292264146085162,"score_spread":0.2678228346197805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}