{"id":"W2047374020","doi":"10.1074/jbc.m100463200","title":"Proteolytic Degradation and Impaired Secretion of an Apolipoprotein A-I Mutant Associated with Dominantly Inherited Hypoalphalipoproteinemia","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; University of Ottawa; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Mutant; Secretion; Apolipoprotein B; Degradation (telecommunications); Endocrinology; Internal medicine; Chemistry; Medicine; Biochemistry; Gene; Cholesterol; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790565,0.0006208293,0.0002847698,0.0002778746,0.0001170835,0.0002971437,0.0001882553,0.0003284361,0.000560834],"category_scores_gemma":[0.0002182635,0.0001907448,0.0002453905,0.0001246543,0.0003032977,0.00012131,0.0001849351,0.000463434,0.0002373031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180337,"about_ca_system_score_gemma":0.0001528421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000432507,"about_ca_topic_score_gemma":0.0004739439,"domain_scores_codex":[0.9998525,0.00002576649,0.00002662176,0.00003284184,0.0000400681,0.00002219472],"domain_scores_gemma":[0.9998079,0.00003473238,0.00006896111,0.00002123739,0.0000143205,0.00005290584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006570172,0.00001479773,0.0003220724,0.000008425104,0.000004794216,0.0002858867,0.000007921833,0.00002666883,0.9988944,0.00002673933,0.000007676501,0.0003349607],"study_design_scores_gemma":[0.00004494693,0.0007801936,0.01253873,0.000006247751,0.00004778961,0.006227968,0.00004656745,0.00139189,0.9779729,0.0000637284,0.0008681931,0.00001075688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980097,0.0003452632,0.001265709,0.00002770617,0.00001241902,0.0000122666,0.0001027098,0.00003551935,0.0001887344],"genre_scores_gemma":[0.9974322,0.0002927539,0.0014068,0.0000273715,0.000007507183,0.00001307463,0.0001975381,0.00001935761,0.0006034565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006208293,"threshold_uncertainty_score":0.001876116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188789547137291,"score_gpt":0.2511213447032504,"score_spread":0.2292334492318775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}