{"id":"W2047391981","doi":"10.1007/s00018-007-7478-z","title":"Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions","year":2008,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Engineering and Physical Sciences Research Council; U.S. Public Health Service; Centers for Disease Control and Prevention; National Institute on Aging; National Institutes of Health","keywords":"Epitope; Antibody; Biology; Mutant; Prion protein; Strain (injury); Recombinant DNA; Residue (chemistry); In vitro; Biochemistry; Virology; Molecular biology; Disease; Immunology; Gene; Anatomy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002507097,0.0002927699,0.0002996401,0.0003360925,0.0004190831,0.0004448716,0.0003896182,0.0005401724,0.002525236],"category_scores_gemma":[0.0006367477,0.0001967195,0.0003301052,0.0001734697,0.0006220654,0.0005506648,0.0003603141,0.0006458628,0.0006273214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357235,"about_ca_system_score_gemma":0.0001838908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004039859,"about_ca_topic_score_gemma":0.0002617989,"domain_scores_codex":[0.9998963,0.00001902165,0.000008107075,0.00003154563,0.00002046683,0.00002454575],"domain_scores_gemma":[0.999292,0.0002814073,0.0001155337,0.00007480311,0.00007562945,0.0001605153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003809108,0.00002904299,0.0005332255,0.00003067264,0.00000529434,0.0003004015,0.00004578726,0.0001256541,0.9970139,0.0004298609,0.00003199339,0.001073184],"study_design_scores_gemma":[0.00004323454,0.0004557943,0.01900828,0.00001309933,0.00002723665,0.002099137,0.0001235305,0.001577944,0.9738448,0.001408811,0.001370871,0.00002725279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919223,0.001037845,0.005723372,0.0001000373,0.00002573075,0.00001257703,0.000147023,0.00004568142,0.0009855238],"genre_scores_gemma":[0.9981877,0.0001363965,0.001167178,0.00003703325,0.00001171716,0.000005997944,0.0001472159,0.000009847088,0.000296836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002525236,"threshold_uncertainty_score":0.008447766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05869433476455511,"score_gpt":0.3001613391968962,"score_spread":0.2414670044323411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}