{"id":"W2047404999","doi":"10.1371/journal.pone.0023726","title":"Pilot, Randomized Study Assessing Safety, Tolerability and Efficacy of Simplified LPV/r Maintenance Therapy in HIV Patients on the 1st PI-Based Regimen","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbott (Canada); McGill University; University of British Columbia","funders":"Abbott Canada","keywords":"Medicine; Lopinavir; Ritonavir; Regimen; Tolerability; Lopinavir/ritonavir; Adverse effect; Internal medicine; Viral load; Randomized controlled trial; Gastroenterology; Human immunodeficiency virus (HIV); Immunology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004027102,0.00141308,0.002864075,0.0004136898,0.0005491324,0.0008285918,0.001131186,0.001424736,0.004649731],"category_scores_gemma":[0.003659325,0.0006544321,0.001426172,0.0003883487,0.001737009,0.001020935,0.0005173531,0.002691149,0.0005621336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008822982,"about_ca_system_score_gemma":0.001751551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009691603,"about_ca_topic_score_gemma":0.001248662,"domain_scores_codex":[0.9977838,0.001504549,0.0001242643,0.0002266495,0.000155789,0.0002049114],"domain_scores_gemma":[0.9957702,0.001418671,0.0008841325,0.0005131627,0.0002523986,0.001161451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.95639,0.02971208,0.002312415,0.0001146003,0.0004671374,0.00004584028,0.00005416057,0.0003265899,0.002169984,0.00004850669,0.0001786441,0.008180065],"study_design_scores_gemma":[0.6488256,0.3468349,0.003297033,0.000006783527,0.0001733579,0.00002644094,0.00001418858,0.0003853861,0.000259768,0.00004973318,0.0001190342,0.000007858484],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960849,0.0003201903,0.0003276549,0.0001256705,0.00009315377,0.002447514,0.0002080212,0.00003383653,0.0003589155],"genre_scores_gemma":[0.9932111,0.0002961709,0.001654326,0.000406005,0.0003151344,0.003065175,0.0005193361,0.000008699039,0.0005240893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004649731,"threshold_uncertainty_score":0.02129757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07806324269220996,"score_gpt":0.2687920100625781,"score_spread":0.1907287673703682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}