{"id":"W2047457389","doi":"10.1182/blood-2013-12-546218","title":"Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Transduction (biophysics); Stem cell; Viral vector; Haematopoiesis; Biology; Hematopoietic stem cell; Gene delivery; Genetic enhancement; Cancer research; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002802024,0.000117923,0.0001277247,0.00005114056,0.00006254147,0.0000230651,0.0001175901,0.00009902187,0.00001015168],"category_scores_gemma":[0.000005411521,0.0001208081,0.00004025708,0.00007205598,0.00007420257,0.000003972756,0.00002638771,0.0000960591,0.000004862354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006444674,"about_ca_system_score_gemma":0.00001926408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007979688,"about_ca_topic_score_gemma":0.000534571,"domain_scores_codex":[0.9990269,0.0001490249,0.0001583554,0.0003244268,0.0001195634,0.0002217108],"domain_scores_gemma":[0.9995846,0.000008475133,0.00003467053,0.0002958609,0.00002337601,0.00005305367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002467307,0.0001511845,0.000469307,0.0000449678,0.00001827553,0.00000170593,0.0001340876,0.000004032505,0.998524,0.00005978515,0.0001107495,0.0002351584],"study_design_scores_gemma":[0.001633714,0.0007143044,0.0004782261,0.00001600644,0.000009795469,0.000002375831,0.0000371524,0.000002793094,0.9956634,0.00009314444,0.001210559,0.0001385176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980806,0.001256724,0.00005941952,0.00009090434,0.00002926723,0.0001636564,0.000006185729,0.00001297215,0.0003002687],"genre_scores_gemma":[0.9977114,0.0001693258,0.00009172927,0.00003967722,0.00009707599,0.000021875,0.00001198673,0.00002507856,0.001831852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002860604,"threshold_uncertainty_score":0.4926412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072544915765371,"score_gpt":0.2473106689048994,"score_spread":0.2365852197472457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}