{"id":"W2047499088","doi":"10.1523/jneurosci.4014-05.2005","title":"A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia<i>In Vivo</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":411,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Stroke Network; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"In vivo; Neuroprotection; Pharmacology; Ischemia; Penumbra; Glutathione; Antioxidant; Chemistry; Stroke (engine); Neurotoxicity; Inducer; Brain damage; Medicine; Biology; Biochemistry; Toxicity; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000750563,0.0002268115,0.0002797097,0.0001741429,0.00008256538,0.00006037212,0.0005407266,0.0001296693,0.000003086313],"category_scores_gemma":[0.00177222,0.0001959988,0.0001565287,0.0003386539,0.0002615493,0.00003157646,0.0001508292,0.0003460095,0.000003581542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006372406,"about_ca_system_score_gemma":0.0002976526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003558169,"about_ca_topic_score_gemma":0.00001283838,"domain_scores_codex":[0.9980924,0.0002442763,0.0004946025,0.0004746159,0.0002787639,0.0004153439],"domain_scores_gemma":[0.9988151,0.00007663073,0.000404857,0.0003030105,0.0002079313,0.0001924888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008445355,0.0002067266,0.002465912,0.00001784299,0.000006657264,0.00005120258,0.0001198104,0.0001747099,0.9951858,0.00000184802,0.0002940783,0.0006309088],"study_design_scores_gemma":[0.0009949512,0.001170665,0.01198627,0.00005903223,0.000006549358,0.000101994,0.00006089234,0.0001512647,0.9810045,0.00001088389,0.004238243,0.0002147702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99829,0.0002681679,0.0002273671,0.0004288228,0.0002151858,0.0003044446,0.0000193718,0.00000650222,0.0002401605],"genre_scores_gemma":[0.9976087,0.00011917,0.0008238028,0.0009864462,0.0002543998,0.00001217061,0.000001513908,0.0000222001,0.0001716506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01418128,"threshold_uncertainty_score":0.7992599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266329966018105,"score_gpt":0.2469338328057578,"score_spread":0.2342705331455768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}