{"id":"W2047513608","doi":"10.1371/journal.pone.0104971","title":"Loss of Intralipid®- but Not Sevoflurane-Mediated Cardioprotection in Early Type-2 Diabetic Hearts of Fructose-Fed Rats: Importance of ROS Signaling","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Sevoflurane; Diabetic cardiomyopathy; Cardioprotection; Pharmacology; Mitochondrial ROS; Carnitine; Ischemia; Medicine; Reperfusion injury; Mitochondrion; Protein kinase B; Reactive oxygen species; Internal medicine; Endocrinology; Chemistry; Anesthesia; Apoptosis; Biochemistry; Oxidative stress; Heart failure; Cardiomyopathy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464633,0.0008366011,0.0005106912,0.0003364881,0.0001547027,0.0002755225,0.000321676,0.000399222,0.001479832],"category_scores_gemma":[0.0001288586,0.0002394256,0.0004614365,0.0001445273,0.0003494997,0.0004361813,0.0001927831,0.001035093,0.0001856866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154834,"about_ca_system_score_gemma":0.000241861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003522794,"about_ca_topic_score_gemma":0.0005234363,"domain_scores_codex":[0.9998821,0.00001137093,0.00001450418,0.00003658631,0.00002084464,0.00003456106],"domain_scores_gemma":[0.9997353,0.00002015617,0.0001027762,0.00002795521,0.00002472291,0.00008923966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001667318,0.00009099215,0.0004007253,0.00003803488,0.00001229252,0.00005279372,0.0000138065,0.00001693393,0.9967284,0.00002551362,0.00001746,0.0009357111],"study_design_scores_gemma":[0.0001141413,0.002241904,0.01882192,0.00001386612,0.00007096287,0.0002152795,0.00005942093,0.0003391693,0.9774674,0.00005338353,0.0005907308,0.00001169183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971649,0.0008059091,0.001335763,0.00007525214,0.0000399973,0.00001986855,0.0002239909,0.00004034261,0.0002940441],"genre_scores_gemma":[0.9938658,0.0009926668,0.002441116,0.00009924874,0.0000283754,0.00009590032,0.0005538829,0.00004096222,0.001882193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479832,"threshold_uncertainty_score":0.004950523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627663132847268,"score_gpt":0.2182952942699654,"score_spread":0.2020186629414927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}