{"id":"W2047513608","doi":"10.1371/journal.pone.0104971","title":"Loss of Intralipid®- but Not Sevoflurane-Mediated Cardioprotection in Early Type-2 Diabetic Hearts of Fructose-Fed Rats: Importance of ROS Signaling","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Sevoflurane; Diabetic cardiomyopathy; Cardioprotection; Pharmacology; Mitochondrial ROS; Carnitine; Ischemia; Medicine; Reperfusion injury; Mitochondrion; Protein kinase B; Reactive oxygen species; Internal medicine; Endocrinology; Chemistry; Anesthesia; Apoptosis; Biochemistry; Oxidative stress; Heart failure; Cardiomyopathy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004020841,0.0001358451,0.000832177,0.0001503033,0.00001661185,0.000002632717,0.00005405251,0.0001686358,0.00003277187],"category_scores_gemma":[0.0004561256,0.0001213898,0.000133045,0.0003550762,0.00011116,0.00005059151,0.00002835617,0.0002289151,0.000005195993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004178962,"about_ca_system_score_gemma":0.00006447125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000300622,"about_ca_topic_score_gemma":0.00001006551,"domain_scores_codex":[0.9984387,0.00007877022,0.0005868744,0.0002187401,0.0004797622,0.0001971883],"domain_scores_gemma":[0.9989279,0.0001118086,0.0002462809,0.0003332006,0.0003043059,0.00007651248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004595466,0.000315204,0.1530798,0.0007937076,0.0001275172,0.000004616202,0.0003770834,0.00002468088,0.8447219,0.000004175844,0.000005251462,0.00008651214],"study_design_scores_gemma":[0.001413897,0.0004840525,0.03453027,0.0010441,0.0002012641,0.000005518156,0.00004873097,0.0002841041,0.9618636,0.00001449553,0.000005268094,0.0001046673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988413,0.000234508,0.00001519256,0.0000994729,0.00008234258,0.0005325954,0.00001416774,0.00002495047,0.0001554387],"genre_scores_gemma":[0.9992466,0.00006604585,0.000409475,0.00002885744,0.0001278315,0.00001447889,0.00002213512,0.00002513787,0.00005944988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1185495,"threshold_uncertainty_score":0.4950133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627663132847268,"score_gpt":0.2182952942699654,"score_spread":0.2020186629414927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}