{"id":"W2047514208","doi":"10.1016/s0306-4522(02)00404-9","title":"Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures","year":2002,"lang":"en","type":"article","venue":"Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"GSK-3; Cholinergic neuron; Tau protein; Biology; Senile plaques; Cholinergic; Basal forebrain; Amyloid precursor protein; Phosphorylation; Neurodegeneration; Kinase; Cell biology; Protein kinase A; Choline acetyltransferase; Alzheimer's disease; Biochemistry; Neuroscience; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004232553,0.0006048541,0.0007219497,0.0006150936,0.000457835,0.0005132863,0.0006412443,0.0004089894,0.001312298],"category_scores_gemma":[0.0002556118,0.0004599504,0.0008010776,0.0003832774,0.000427931,0.0005190911,0.0005081391,0.001808894,0.001092671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004885268,"about_ca_system_score_gemma":0.0005390504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003231975,"about_ca_topic_score_gemma":0.005953134,"domain_scores_codex":[0.9996527,0.00002973489,0.00005217481,0.00007121848,0.0001002404,0.00009391143],"domain_scores_gemma":[0.999458,0.0001514039,0.00006798611,0.00009107477,0.00008153432,0.000150037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002595746,0.00006021386,0.0002282865,0.00003776628,0.00001344014,0.0002269205,0.00005975541,0.00003071735,0.998511,0.00005877465,0.00002866336,0.0004847672],"study_design_scores_gemma":[0.00004118825,0.0005301192,0.007311861,0.00001896627,0.00005748797,0.0004562778,0.0001531601,0.0003659998,0.9904239,0.00007324535,0.0005610439,0.000006779021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929576,0.002140659,0.001457641,0.00009383486,0.0000691875,0.00003317874,0.0006562638,0.00004704349,0.002544555],"genre_scores_gemma":[0.984487,0.003318685,0.00282125,0.00008685224,0.0000325395,0.00008938347,0.001636977,0.00005048043,0.007476732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003231975,"threshold_uncertainty_score":0.006426334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319018565445556,"score_gpt":0.3009142588629724,"score_spread":0.2690124023184168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}