{"id":"W2047515039","doi":"10.1371/journal.pone.0059706","title":"Human Coding Synonymous Single Nucleotide Polymorphisms at Ramp Regions of mRNA Translation","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University","funders":"Eli Lilly Canada; Eli Lilly and Company","keywords":"CpG site; Genetics; Biology; Coding region; Codon usage bias; Stop codon; Translational efficiency; Silent mutation; Gene; Genome; Translation (biology); Messenger RNA; Mutation; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004941673,0.0002345514,0.0004061563,0.0006049749,0.0002325737,0.0003851998,0.0001600266,0.0002883256,0.0014637],"category_scores_gemma":[0.0009708895,0.0001292885,0.0003949015,0.0006119915,0.0003370656,0.0001713752,0.0001847345,0.00031622,0.0004123676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508078,"about_ca_system_score_gemma":0.0001395344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000335206,"about_ca_topic_score_gemma":0.0006150086,"domain_scores_codex":[0.9994961,0.0001258381,0.00004633491,0.0001926503,0.00009635848,0.00004269281],"domain_scores_gemma":[0.999109,0.0003457515,0.0002896163,0.00008286291,0.00008508585,0.00008765877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001615475,0.00006622491,0.2880564,0.0003485385,0.000361467,0.001915679,0.0003745297,0.001513334,0.6830068,0.002022735,0.0003833323,0.02033553],"study_design_scores_gemma":[0.00007023146,0.0006707776,0.8862338,0.00007755652,0.0003689673,0.004834592,0.0002687565,0.01097558,0.08873907,0.003531035,0.004168372,0.00006116262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930789,0.001149117,0.004024795,0.00003785837,0.00002039243,0.00001687452,0.0004370584,0.00005038498,0.001184559],"genre_scores_gemma":[0.9978539,0.0001397359,0.001420302,0.00005165282,0.00001293122,0.00001230094,0.0003323129,0.000009662288,0.0001669547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0014637,"threshold_uncertainty_score":0.004896581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04777709948731172,"score_gpt":0.2247079676808511,"score_spread":0.1769308681935394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}