{"id":"W2047537157","doi":"10.4161/cc.22776","title":"BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment","year":2012,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Biology; Cancer research; Stromal cell; Oxidative stress; Cancer cell; Tumor microenvironment; Cell culture; Downregulation and upregulation; Cancer; Fibroblast; Cell biology; Endocrinology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000622298,0.00006386808,0.00005091288,0.00001346349,0.00004778922,0.00001501481,0.0000734394,0.00002606805,0.00001357282],"category_scores_gemma":[0.00001389714,0.00005318484,0.00002243135,0.00003159825,0.00005418152,0.000002421529,0.00005675482,0.00003962773,0.000009733385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001251384,"about_ca_system_score_gemma":0.00001122684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004487672,"about_ca_topic_score_gemma":0.00009576407,"domain_scores_codex":[0.999601,0.00002590124,0.00007452978,0.000116199,0.00004122349,0.0001411595],"domain_scores_gemma":[0.9997505,0.00002602627,0.00003108215,0.0001470484,0.000005987985,0.00003934071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004214486,0.000658838,0.1373187,0.00003254195,0.00004316031,0.000008685292,0.00356673,0.0008710035,0.8530994,0.0002146832,0.00223617,0.001907923],"study_design_scores_gemma":[0.0008063076,0.0001339627,0.1844533,0.000009027199,0.00005003877,0.000008741415,0.003246585,0.00006825932,0.7818353,0.0001366504,0.02901179,0.0002400416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967692,0.001704138,0.0001171025,0.0000995899,0.00004152567,0.000120009,0.0000446889,0.000001222937,0.001102458],"genre_scores_gemma":[0.9988536,0.0003058623,0.0002287329,0.0003542315,0.00009334042,0.00002836575,0.0000652295,0.000007016076,0.00006365588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07126409,"threshold_uncertainty_score":0.2168815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004519010655143739,"score_gpt":0.2102420311755439,"score_spread":0.2057230205204002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}