{"id":"W2047547950","doi":"10.1021/jo8023494","title":"Biomimetic Transannular Oxa-Conjugate Addition Approach to the 2,6-Disubstituted Dihydropyran of Laulimalide Yields an Unprecedented Transannular Oxetane","year":2009,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Dihydropyran; Oxetane; Polyketide; Conjugate; Chemistry; Stereochemistry; Structural isomer; Biosynthesis; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001892115,0.0005397717,0.0008216721,0.00005523167,0.000223987,0.00006474025,0.002105136,0.0004200673,0.004449429],"category_scores_gemma":[0.000546565,0.0003624593,0.0004044833,0.0007330952,0.0002954556,0.0001985739,0.00004673247,0.001111058,0.000009706842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001884213,"about_ca_system_score_gemma":0.0002397897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000107698,"about_ca_topic_score_gemma":0.000002039241,"domain_scores_codex":[0.9964342,0.0001972437,0.001429694,0.0004137383,0.0009637964,0.0005613466],"domain_scores_gemma":[0.9966371,0.0003481923,0.0008188264,0.001428761,0.0003565555,0.000410568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004592788,0.0005613184,0.00001046049,0.0001912702,0.0002419012,0.00002069728,0.001836438,0.0002469567,0.9943049,0.000003995396,0.0002692352,0.001853554],"study_design_scores_gemma":[0.001415608,0.0001036817,0.00007503169,0.0002556204,0.0008003964,0.001756444,0.001790235,0.0003940504,0.9916704,0.0002189734,0.00112097,0.000398643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976752,0.0008782038,0.01527797,0.003379317,0.00009760694,0.0001961588,0.00008859565,0.00008282452,0.003247282],"genre_scores_gemma":[0.9962928,0.0001659635,0.002417068,0.0001847824,0.0005457568,0.000004009335,0.00004206757,0.00007879994,0.0002687473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01954076,"threshold_uncertainty_score":0.9998828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516315269689081,"score_gpt":0.2512400961392329,"score_spread":0.2360769434423421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}