{"id":"W2047579438","doi":"10.1038/ncomms6874","title":"Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Universität zu Köln; Stem Cell Network","keywords":"Hair follicle; Mutant; Biology; Cancer research; Stem cell; DNA damage; Cell biology; Mutation; Cell; Cell growth; DNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760376,0.0002581272,0.0002041476,0.0002846248,0.0001209887,0.000381952,0.0001826454,0.0002372126,0.0005582434],"category_scores_gemma":[0.0001515473,0.0001156175,0.0001640803,0.0001245151,0.0002995566,0.0001891973,0.0001864665,0.0004019063,0.0001912844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002516379,"about_ca_system_score_gemma":0.0001877135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003754726,"about_ca_topic_score_gemma":0.000717396,"domain_scores_codex":[0.9998353,0.0000332495,0.00001704992,0.00002735462,0.0000435316,0.00004351084],"domain_scores_gemma":[0.99984,0.00004721648,0.00004548913,0.00002783337,0.000008816099,0.00003051981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004545154,0.00001060754,0.0001925231,0.00001231845,0.000002235141,0.00004401992,0.00001096945,0.0001040039,0.9981949,0.0001194642,0.00001550034,0.00124806],"study_design_scores_gemma":[0.000007961816,0.0001519626,0.002012734,0.000002532049,0.000006741232,0.0001858569,0.00002069463,0.001123734,0.9951869,0.00007070471,0.001227829,0.000002370818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954274,0.001292491,0.002163598,0.00005684281,0.000011468,0.00001388701,0.00009612184,0.0001042771,0.0008338763],"genre_scores_gemma":[0.9984597,0.0003869275,0.0006652754,0.000009898484,0.000002426894,0.000007211313,0.00005050546,0.000009317558,0.0004086912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005582434,"threshold_uncertainty_score":0.001867533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649883980516796,"score_gpt":0.2868759513575916,"score_spread":0.2603771115524237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}