{"id":"W2047594294","doi":"10.1074/jbc.m400732200","title":"Mevalonate Promotes the Growth of Tumors Derived from Human Cancer Cells in Vivo and Stimulates Proliferation in Vitro with Enhanced Cyclin-dependent Kinase-2 Activity","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mevalonate pathway; Cyclin-dependent kinase; Biology; CDK inhibitor; In vivo; Cell growth; Endocrinology; Cyclin; Cancer research; Internal medicine; Kinase; Cancer cell; HMG-CoA reductase; Cancer; Reductase; Biochemistry; Cell cycle; Enzyme; Medicine; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232016,0.0004424618,0.0002991431,0.0003823329,0.0001699377,0.0003219809,0.0001114294,0.0001708477,0.00136369],"category_scores_gemma":[0.0001267805,0.000162778,0.0002240897,0.0002296201,0.0001996385,0.0001534348,0.0002448742,0.0003125634,0.0003842337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997795,"about_ca_system_score_gemma":0.0002564652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338759,"about_ca_topic_score_gemma":0.002037644,"domain_scores_codex":[0.9998758,0.0000237335,0.00001019328,0.00001986669,0.00004007767,0.00003027368],"domain_scores_gemma":[0.999899,0.00002414937,0.00002505329,0.00001211398,0.000009421633,0.0000302741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002797092,0.00004918968,0.0005078557,0.000036857,0.000008358787,0.00004878617,0.0000116155,0.00003381937,0.9973493,0.00005153652,0.00004141242,0.00158149],"study_design_scores_gemma":[0.00003162712,0.0008329602,0.01130896,0.000006286113,0.00002039138,0.0006057349,0.00002915912,0.0002431534,0.983946,0.00005952603,0.002912216,0.000003945132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898425,0.006104235,0.001297106,0.00009905307,0.0000322403,0.00003519486,0.0003341428,0.00008338122,0.002172277],"genre_scores_gemma":[0.9933046,0.002804872,0.001477655,0.00002781486,0.00001355548,0.0000237566,0.0004578637,0.00001631866,0.001873562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00136369,"threshold_uncertainty_score":0.00456202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103792234583873,"score_gpt":0.2500059057955076,"score_spread":0.2389679834496689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}