{"id":"W2047619014","doi":"10.1093/nar/gkp636","title":"The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Université de Sherbrooke","keywords":"Biology; Telomere; Telomerase; Ribonucleoprotein; Telomere-binding protein; Heterogeneous nuclear ribonucleoprotein; Molecular biology; Cell biology; DNA; DNA-PKcs; DNA repair; DNA damage; Phosphorylation; Protein kinase A; Biochemistry; RNA; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008695277,0.0002833836,0.00009939754,0.0002033062,0.0001533122,0.0002003834,0.00009694202,0.0001693973,0.000939489],"category_scores_gemma":[0.000182859,0.0001140534,0.0001477856,0.0001111229,0.0001421217,0.0001395565,0.0001595765,0.0001905388,0.0004473897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174434,"about_ca_system_score_gemma":0.0001251189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000366355,"about_ca_topic_score_gemma":0.000616801,"domain_scores_codex":[0.9999369,0.00001156822,0.000003926247,0.00001862671,0.00001751692,0.00001143984],"domain_scores_gemma":[0.9999399,0.00001483065,0.00001952211,0.000008262652,0.000004405634,0.00001300284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007776193,0.00001799929,0.0006056579,0.00005151797,0.000006326641,0.00007586081,0.00001445197,0.00009395259,0.9940878,0.0001217436,0.00006857311,0.004778516],"study_design_scores_gemma":[0.00002241935,0.0003459844,0.02259325,0.00001395962,0.00002202385,0.001158936,0.00002965262,0.001646855,0.9670583,0.0002085871,0.006895012,0.000005073085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830224,0.01130062,0.003274218,0.0001338054,0.00003858561,0.00003664713,0.0002589741,0.00006436987,0.001870387],"genre_scores_gemma":[0.991843,0.002982968,0.001403096,0.00002853515,0.00001765476,0.00001547887,0.0005145137,0.00000586022,0.003188844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000939489,"threshold_uncertainty_score":0.003142893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038168971374892,"score_gpt":0.334878647351353,"score_spread":0.2944969576376041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}