{"id":"W2047619014","doi":"10.1093/nar/gkp636","title":"The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Université de Sherbrooke","keywords":"Biology; Telomere; Telomerase; Ribonucleoprotein; Telomere-binding protein; Heterogeneous nuclear ribonucleoprotein; Molecular biology; Cell biology; DNA; DNA-PKcs; DNA repair; DNA damage; Phosphorylation; Protein kinase A; Biochemistry; RNA; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002629599,0.0005660478,0.000628094,0.0003887722,0.003223668,0.0005438215,0.00161297,0.0002788684,0.0006327834],"category_scores_gemma":[0.0006701033,0.0003508523,0.0002942,0.001242879,0.0008485001,0.0001950849,0.0005342929,0.002009004,0.001327032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004869601,"about_ca_system_score_gemma":0.0002026803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006529092,"about_ca_topic_score_gemma":0.00008075168,"domain_scores_codex":[0.9928308,0.0007167075,0.0007748429,0.00108169,0.002622026,0.001973981],"domain_scores_gemma":[0.9957647,0.0003037848,0.0001572787,0.00223804,0.0005975086,0.0009386521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001362969,0.0006462071,0.0002671435,0.00005851356,0.0001156601,0.000627213,0.001357285,0.00000993613,0.9022764,0.001294094,0.004253366,0.08773121],"study_design_scores_gemma":[0.003326923,0.003904157,0.02828092,0.0005795397,0.00006821127,0.0002764983,0.001978606,0.0004022133,0.7895554,0.00177028,0.1688809,0.0009763522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972582,0.0007289345,0.000009386046,0.01906825,0.0001245851,0.003947548,0.00002355896,0.0002886717,0.003227056],"genre_scores_gemma":[0.9927562,0.0002043996,0.000268011,0.001415849,0.0004387264,0.0001979357,0.00001553177,0.0001422209,0.004561119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1646275,"threshold_uncertainty_score":0.9998943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038168971374892,"score_gpt":0.334878647351353,"score_spread":0.2944969576376041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}