{"id":"W2047640421","doi":"10.1021/bi100516e","title":"Compound Ice-Binding Site of an Antifreeze Protein Revealed by Mutagenesis and Fluorescent Tagging","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Antifreeze protein; Ice crystals; Antifreeze; Chemistry; Binding site; Gene isoform; Mutagenesis; Biophysics; Crystallography; Mutant; Biochemistry; Biology; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007804157,0.0001053715,0.000111893,0.000005642249,0.00008317137,0.0000152428,0.0001376241,0.000094681,0.0002951745],"category_scores_gemma":[0.00004001324,0.00008578727,0.00002992642,0.00008881639,0.0002759445,0.00005816729,0.0001353907,0.0001190058,0.00002097425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000154942,"about_ca_system_score_gemma":0.000004828737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008422816,"about_ca_topic_score_gemma":0.000005454942,"domain_scores_codex":[0.9992627,0.00001130204,0.0001464381,0.0002799264,0.0001381651,0.000161506],"domain_scores_gemma":[0.9995935,0.00001789992,0.00007302155,0.0001791712,0.000006622487,0.0001297609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009937887,0.0001044339,0.002392521,0.00002270912,0.000002947678,0.000001519098,0.00001311186,6.292184e-7,0.9960188,0.00000226874,0.0004329266,0.0009982405],"study_design_scores_gemma":[0.0001342,0.00002084354,0.00823685,0.000014164,0.00000577747,0.000003900452,0.00001528221,0.0002062373,0.9907511,0.00006069728,0.0004257301,0.0001251886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999172,0.0000248059,0.000007848203,0.00009660317,0.00001496485,0.0001005855,0.00007366394,0.00002467019,0.0004848343],"genre_scores_gemma":[0.9973005,0.000003980676,0.002250279,0.00004010206,0.00003095714,0.000008903925,0.00008301483,0.000005593239,0.0002766713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005844329,"threshold_uncertainty_score":0.3498304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007032654225205947,"score_gpt":0.2074116998399601,"score_spread":0.2003790456147542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}