{"id":"W2047661097","doi":"10.1074/jbc.m108815200","title":"Biogenesis of p53 Involves Cotranslational Dimerization of Monomers and Posttranslational Dimerization of Dimers","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"National Cancer Institute; Fondation pour la Recherche Médicale","keywords":"Mutant; Biogenesis; Wild type; Polysome; Dimer; Cell biology; Biology; Protein subunit; Immunoprecipitation; Gene; Biochemistry; Chemistry; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001313581,0.000110964,0.0003804778,0.00007714987,0.00001770384,0.000001973676,0.00006317394,0.0001977157,0.0002855929],"category_scores_gemma":[0.0001297109,0.00008901392,0.0001623174,0.000234561,0.0002774436,0.00005086458,0.00001033071,0.0001282153,2.265763e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002091903,"about_ca_system_score_gemma":0.00005793071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004496605,"about_ca_topic_score_gemma":1.276553e-7,"domain_scores_codex":[0.9987901,0.00002843747,0.0006970289,0.0001175059,0.0002766488,0.00009028256],"domain_scores_gemma":[0.9988255,0.00008711246,0.0006351822,0.00008259344,0.0002839906,0.00008562371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002678483,0.0001728357,0.02812332,0.0001431998,0.0001613601,0.000002636662,0.000111282,0.0003095759,0.9686913,0.00002010325,0.00001807918,0.001978417],"study_design_scores_gemma":[0.00128538,0.0003760947,0.0377785,0.0001665154,0.0001556189,0.0000713644,0.00006326621,0.0007069562,0.959124,0.0000686952,0.0001134448,0.00009017091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934956,0.003912546,0.001810341,0.0002765213,0.00004142888,0.00008521289,0.00006632328,0.000004562037,0.0003074027],"genre_scores_gemma":[0.9969798,0.001102281,0.001754212,0.00002337695,0.00004991257,8.933175e-7,0.00007084105,0.000008131513,0.00001050497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009655186,"threshold_uncertainty_score":0.3629882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03396810249891474,"score_gpt":0.2390327535422684,"score_spread":0.2050646510433537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}