{"id":"W2047680094","doi":"10.1006/bbrc.2001.6030","title":"Wild-Type and Mutated Nicastrins Do Not Display Aminopeptidase M- and B-like Activities","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; National Center for Theoretical Sciences","keywords":"Missense mutation; Nicastrin; Presenilin; Aminopeptidase; Biology; Enzyme; Wild type; Phenotype; HEK 293 cells; Amyloid precursor protein; Sorting nexin; Biochemistry; Genetics; Molecular biology; Gene; Alzheimer's disease; Mutant; Leucine; Disease; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252234,0.0003750853,0.0003547284,0.0003358518,0.0002423789,0.0004865088,0.000462373,0.0005161635,0.001621846],"category_scores_gemma":[0.0003374319,0.0001756923,0.0002559083,0.0003019658,0.0004694217,0.0002865621,0.0003457186,0.0004594011,0.0007178352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005362818,"about_ca_system_score_gemma":0.000174685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002802795,"about_ca_topic_score_gemma":0.001329465,"domain_scores_codex":[0.9998012,0.00002186674,0.00002414788,0.00003167508,0.00006618586,0.00005490917],"domain_scores_gemma":[0.999648,0.00007633911,0.0000754866,0.00005198236,0.00004014545,0.0001081415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003555827,0.00002352375,0.000634897,0.00002629693,0.00002086877,0.0003046513,0.0000542771,0.000118877,0.9973441,0.0002601153,0.00006582422,0.000791003],"study_design_scores_gemma":[0.00001821049,0.0000993213,0.007992928,0.000004338077,0.00003352278,0.001656455,0.0001188639,0.00095998,0.9850546,0.0000800745,0.003969372,0.00001234676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967738,0.0004331148,0.0008035547,0.00005055499,0.00003218077,0.00001077593,0.0003328865,0.00003829978,0.001524936],"genre_scores_gemma":[0.9935586,0.0002064127,0.0008875121,0.00003753147,0.000007602008,0.00001670495,0.001437009,0.0000323299,0.00381631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002802795,"threshold_uncertainty_score":0.005572975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08601902642172479,"score_gpt":0.3884692551825691,"score_spread":0.3024502287608444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}