{"id":"W2047680094","doi":"10.1006/bbrc.2001.6030","title":"Wild-Type and Mutated Nicastrins Do Not Display Aminopeptidase M- and B-like Activities","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; National Center for Theoretical Sciences","keywords":"Missense mutation; Nicastrin; Presenilin; Aminopeptidase; Biology; Enzyme; Wild type; Phenotype; HEK 293 cells; Amyloid precursor protein; Sorting nexin; Biochemistry; Genetics; Molecular biology; Gene; Alzheimer's disease; Mutant; Leucine; Disease; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002348833,0.0001372039,0.000248204,0.0001409405,0.0003675556,0.0000996348,0.0001631493,0.0001019119,0.00003525384],"category_scores_gemma":[0.0003453694,0.0001067803,0.00004924487,0.0006789613,0.001686925,0.00009742768,0.0004843439,0.000544165,0.0000169491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003102974,"about_ca_system_score_gemma":0.00005539437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008839622,"about_ca_topic_score_gemma":0.00001175526,"domain_scores_codex":[0.998724,0.0001401507,0.00018778,0.000314863,0.0003349538,0.0002982367],"domain_scores_gemma":[0.9981424,0.0005205385,0.00003046751,0.0006513702,0.0002255846,0.0004296118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000216366,0.0005415547,0.001517096,0.00004501702,0.0000594166,0.00001121834,0.0001079514,1.639857e-8,0.988147,0.0016427,0.001043651,0.006667989],"study_design_scores_gemma":[0.01150979,0.003947224,0.2075421,0.00357618,0.0007967483,0.0009549504,0.005711353,0.01432381,0.6543613,0.003269021,0.09177738,0.002230159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896077,0.0004867937,0.000007460376,0.008478677,0.000003207811,0.0001727915,0.00003261131,0.00003806736,0.001172692],"genre_scores_gemma":[0.9942878,0.003933945,0.0004390143,0.0002400477,0.00005874391,0.00002515954,0.0001241175,0.00001127157,0.0008798814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3337857,"threshold_uncertainty_score":0.6215544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08601902642172479,"score_gpt":0.3884692551825691,"score_spread":0.3024502287608444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}