{"id":"W2047682874","doi":"10.4161/21624011.2014.945378","title":"Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using<i>ex vivo</i>myeloid-derived suppressor cells as a readout of therapeutic efficacy","year":2014,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Ex vivo; Cancer research; Interleukin 12; Priming (agriculture); Gene silencing; Cytokine; Interleukin 10; Small hairpin RNA; Melanoma; T cell; Immunology; Immunotherapy; Cancer immunotherapy; FOXP3; Immune system; Biology; In vivo; Medicine; Cytotoxic T cell; Cell culture; In vitro; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003479964,0.0005674459,0.001397063,0.0003172529,0.0001883068,0.0000270944,0.0007068902,0.0006472901,0.0005438964],"category_scores_gemma":[0.000298965,0.000540831,0.0001554024,0.000268014,0.0004205574,0.0001240953,0.0004100362,0.0005404761,0.0002483983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008876409,"about_ca_system_score_gemma":0.0001111314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002988378,"about_ca_topic_score_gemma":0.000006103169,"domain_scores_codex":[0.9968724,0.0004960701,0.000858236,0.0007904439,0.00007869192,0.000904215],"domain_scores_gemma":[0.9973324,0.0008993873,0.0004575336,0.001036542,0.0002229634,0.00005116245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001550038,0.0002109076,0.000231729,0.00008422085,0.0004635618,0.00001458829,0.001914179,0.0004251786,0.9874941,0.00006582523,0.00003890333,0.00750684],"study_design_scores_gemma":[0.004877353,0.001023415,0.01256702,0.0001731753,0.0001980221,0.0003393407,0.000176458,0.0003477676,0.9616135,0.00003522735,0.01805856,0.0005901668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932557,0.002919267,0.0006429006,0.0002497826,0.001722322,0.0007562974,0.00005625557,0.0001520808,0.0002453694],"genre_scores_gemma":[0.996747,0.000459402,0.0008344525,0.0004689805,0.00007783493,0.00002820938,0.00004905642,0.00009533043,0.001239708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02588053,"threshold_uncertainty_score":0.9997043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170403258089182,"score_gpt":0.2438292344512137,"score_spread":0.2321252018703219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}