{"id":"W2047682874","doi":"10.4161/21624011.2014.945378","title":"Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using<i>ex vivo</i>myeloid-derived suppressor cells as a readout of therapeutic efficacy","year":2014,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Ex vivo; Cancer research; Interleukin 12; Priming (agriculture); Gene silencing; Cytokine; Interleukin 10; Small hairpin RNA; Melanoma; T cell; Immunology; Immunotherapy; Cancer immunotherapy; FOXP3; Immune system; Biology; In vivo; Medicine; Cytotoxic T cell; Cell culture; In vitro; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729532,0.000448238,0.0002210222,0.0001521794,0.00008935427,0.0003682763,0.0001622224,0.000250397,0.0009588393],"category_scores_gemma":[0.0001146804,0.00009145535,0.0001456161,0.0001029164,0.0002075211,0.0002305933,0.0001247477,0.0009289586,0.0003253285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006182,"about_ca_system_score_gemma":0.0001571819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001084004,"about_ca_topic_score_gemma":0.000240376,"domain_scores_codex":[0.9998627,0.00002834111,0.00001122322,0.00002561383,0.00003165263,0.00004044906],"domain_scores_gemma":[0.9999017,0.00001515774,0.00003888027,0.00001249127,0.00001192573,0.00001986016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001015494,0.00007309458,0.0001009122,0.00001483148,0.000003341693,0.000007010995,0.000005592889,0.0001120382,0.9977192,0.0001419991,0.00004455123,0.001675828],"study_design_scores_gemma":[0.00002626053,0.0005117236,0.0002787455,0.000001903713,0.000009555602,0.00004350279,0.000006457842,0.000534057,0.9976044,0.00003948445,0.0009424923,0.000001435828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875242,0.00080303,0.008897571,0.0001138637,0.00008504079,0.0001002109,0.0002842083,0.000150134,0.002041842],"genre_scores_gemma":[0.9932822,0.0003381872,0.004703975,0.00005978269,0.00002310074,0.00005358411,0.0003263681,0.00002947111,0.001183328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009588393,"threshold_uncertainty_score":0.003207624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170403258089182,"score_gpt":0.2438292344512137,"score_spread":0.2321252018703219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}