{"id":"W2047701184","doi":"10.1038/mp.2011.79","title":"Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans","year":2011,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Tryptophan hydroxylase; TPH2; Serotonin; Orbitofrontal cortex; Single-nucleotide polymorphism; Biology; Serotonergic; Endocrinology; Internal medicine; Genetics; Neuroscience; Genotype; Gene; Medicine; Prefrontal cortex","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282525,0.0002253401,0.0001990453,0.0003142788,0.0002859776,0.0003385512,0.0001390328,0.0003629393,0.001210004],"category_scores_gemma":[0.000443877,0.0002468214,0.0002349427,0.000219836,0.0002821766,0.0001121539,0.0001209153,0.000298524,0.0001014452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212252,"about_ca_system_score_gemma":0.0001198582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006822953,"about_ca_topic_score_gemma":0.008683178,"domain_scores_codex":[0.9999405,0.00001538835,0.000003494774,0.0000221956,0.000008710641,0.000009753585],"domain_scores_gemma":[0.9997932,0.00005969843,0.00007902017,0.00002418682,0.00001357348,0.00003024354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002836809,0.00008535547,0.9487611,0.00002386776,0.0004004395,0.0008380411,0.0003377974,0.0003020783,0.04202179,0.0002741746,0.0003027396,0.003815799],"study_design_scores_gemma":[0.00001821228,0.00004303996,0.9984053,0.000002825922,0.00005902084,0.0004144281,0.00005386629,0.0002384511,0.0005538731,0.0001047768,0.0001020872,0.000004069832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995733,0.00008813675,0.00006589238,0.00003512799,0.000002965006,0.000001145177,0.00005642855,0.000001190726,0.0001757745],"genre_scores_gemma":[0.9996573,0.00004202118,0.0000647737,0.00001832703,0.000004035062,0.000001340533,0.00006258325,0.00000270057,0.0001469524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006822953,"threshold_uncertainty_score":0.01356643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02378624549569739,"score_gpt":0.2520707461651508,"score_spread":0.2282845006694534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}