{"id":"W2047719789","doi":"10.4161/cbt.11.7.14720","title":"Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer","year":2011,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Cancer Institute; University of Toronto","keywords":"Pancreatic cancer; Biology; Cancer research; Pancreas; HDAC1; Zebrafish; Hedgehog signaling pathway; Cancer; Cyclin E1; Cell growth; Cell cycle; Cell biology; Signal transduction; Endocrinology; Cyclin D1; Histone deacetylase; Histone; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521858,0.0001385041,0.0001613632,0.00004437624,0.00006290498,0.000005257478,0.0000717298,0.0001443554,0.0000410602],"category_scores_gemma":[0.00001239856,0.0001213782,0.00003017231,0.00004555731,0.00007295657,0.000003651374,0.00002061172,0.00004003533,8.170096e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004013218,"about_ca_system_score_gemma":0.0001428609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001657195,"about_ca_topic_score_gemma":0.0003481644,"domain_scores_codex":[0.999177,0.00004405896,0.0002157468,0.0003283544,0.00003179766,0.0002030307],"domain_scores_gemma":[0.9996537,0.000008574806,0.00008263125,0.0001390684,0.00006995698,0.00004605768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004901083,0.00004603698,0.03913701,0.00001299521,0.00005803295,2.796271e-7,0.0009066099,0.000003310604,0.8817649,0.00006124359,0.00005033642,0.07746907],"study_design_scores_gemma":[0.001395025,0.0002970394,0.01875047,0.00001269765,0.000009154048,4.920476e-7,0.00002116327,0.0000299062,0.9394322,0.0003827009,0.03950103,0.0001680913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97251,0.02518558,0.001400953,0.000178181,0.0001748279,0.0004473706,0.00003618853,0.000006844081,0.00006003539],"genre_scores_gemma":[0.9795015,0.01622867,0.002336961,0.000514978,0.0001980659,0.0008028346,0.00009043599,0.00002063284,0.0003059506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07730098,"threshold_uncertainty_score":0.4949659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05415920360400744,"score_gpt":0.3335732901656795,"score_spread":0.2794140865616721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}