{"id":"W2047720977","doi":"10.1111/hae.12329","title":"Safety of recombinant activated factor VII (<scp>rFVII</scp>a) in patients with congenital haemophilia with inhibitors: overall <scp>rFVII</scp>a exposure and intervals following high (&gt;240 μg kg<sup>−1</sup>) <scp>rFVII</scp>a doses across clinical trials and registries","year":2013,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Masarykova Univerzita; Novo Nordisk","keywords":"Dosing; Medicine; Haemophilia; Haemophilia A; Recombinant factor VIIa; Incidence (geometry); Anesthesia; Pharmacology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003763747,0.0002026062,0.0008792165,0.0006420736,0.0001660975,0.000872755,0.0002133907,0.0003053393,0.0009156766],"category_scores_gemma":[0.007345325,0.0001175994,0.001169926,0.001297556,0.0002419284,0.000353368,0.0003035687,0.000557677,0.0001693197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006467396,"about_ca_system_score_gemma":0.0007733606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125012,"about_ca_topic_score_gemma":0.001277412,"domain_scores_codex":[0.9969833,0.001181258,0.0005087468,0.0004491088,0.0007129213,0.000164463],"domain_scores_gemma":[0.9901161,0.003816804,0.004561136,0.0004178372,0.0006184882,0.0004696296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01913319,0.0001716012,0.891547,0.0004559036,0.002397808,0.0002060032,0.0002166753,0.001359787,0.001742632,0.0001556008,0.000804911,0.08180887],"study_design_scores_gemma":[0.0005897037,0.01094399,0.9822479,0.00009217354,0.001139036,0.000871649,0.0001020787,0.0007425366,0.001280936,0.0001340422,0.001840373,0.00001558625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923462,0.004950665,0.0003546892,0.00009858995,0.000006289639,0.00005484443,0.001285997,0.00001489497,0.0008879106],"genre_scores_gemma":[0.9979528,0.0008418094,0.0001910126,0.00004001165,0.00002012094,0.00002441664,0.0008115584,0.000003761338,0.0001145527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003763747,"threshold_uncertainty_score":0.01990485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04033435876398517,"score_gpt":0.3239931797907993,"score_spread":0.2836588210268142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}