{"id":"W2047729770","doi":"10.1074/jbc.m114.553743","title":"Cytoskeletal Reorganization Evoked by Rho-associated kinase- and Protein Kinase C-catalyzed Phosphorylation of Cofilin and Heat Shock Protein 27, Respectively, Contributes to Myogenic Constriction of Rat Cerebral Arteries","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Cofilin; Cell biology; Myosin light-chain kinase; Hsp27; Phosphorylation; Rho-associated protein kinase; Actin cytoskeleton; Myosin; Actin; Cytoskeleton; Biology; Chemistry; Biochemistry; Heat shock protein; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323219,0.0001437402,0.0003078209,0.00003504958,0.00005618759,0.00001888582,0.00008306717,0.000243747,0.00002512763],"category_scores_gemma":[0.001194813,0.0001193505,0.00008115868,0.0001300221,0.0001167017,0.0000117852,0.0000691785,0.0001345374,2.540755e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003736957,"about_ca_system_score_gemma":0.00004629008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009171771,"about_ca_topic_score_gemma":0.000002198547,"domain_scores_codex":[0.9989727,0.00008952736,0.0004892853,0.0002095225,0.0001098905,0.0001291392],"domain_scores_gemma":[0.9989016,0.00003102297,0.0004676703,0.0001101879,0.0004008966,0.00008860369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004914098,0.000129093,0.001849035,0.00003113916,0.00006376395,7.209621e-7,0.00001133424,0.000002759529,0.997009,0.00005583463,0.0001699623,0.0001859879],"study_design_scores_gemma":[0.00101891,0.0007957135,0.001091521,0.00007690871,0.00003008373,0.0000201916,0.00008963597,0.00009226107,0.9958006,0.0002489295,0.0006176432,0.0001175992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959776,0.0005826204,0.002878742,0.0001630703,0.00005073043,0.0002441939,0.00005204518,0.000004660033,0.00004633675],"genre_scores_gemma":[0.9993593,0.00008118376,0.0002274446,0.00001754644,0.00005155865,0.000006903677,0.0001452631,0.000009164513,0.0001017147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003381619,"threshold_uncertainty_score":0.4866972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005989354160308808,"score_gpt":0.2117468289461092,"score_spread":0.2057574747858004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}