{"id":"W2047734512","doi":"10.1021/bi035432b","title":"Metal Ion Binding Properties and Conformational States of Calcium- and Integrin-Binding Protein","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Biophysics; Conformational change; Calcium; Protein structure; Calcium-binding protein; Calmodulin; Binding site; Integrin; Binding domain; EF hand; Protein secondary structure; Biochemistry; Plasma protein binding; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065161,0.0001225017,0.0001034037,0.00002109316,0.00005484585,0.00002133899,0.00007666029,0.0001033962,0.000005316192],"category_scores_gemma":[0.0001059752,0.0001092429,0.00003268322,0.00003749075,0.0001820533,0.000006144919,0.0001011967,0.00006207766,0.000001154634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001644822,"about_ca_system_score_gemma":0.00009854628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001110254,"about_ca_topic_score_gemma":4.292802e-7,"domain_scores_codex":[0.999378,0.000009627163,0.0001749998,0.0001973131,0.0001094951,0.000130568],"domain_scores_gemma":[0.9996526,0.000004237628,0.00008475808,0.0001256013,0.00005873727,0.00007410571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005539376,0.00002671933,0.0004788382,0.000192023,0.00003408053,0.000001244406,0.00007083247,0.00001738987,0.9989192,0.00004435163,0.00001854271,0.0001414147],"study_design_scores_gemma":[0.000487213,0.00005495002,0.00004322937,0.0001168506,0.00001446116,0.00002058191,0.0003087492,0.00001615086,0.998676,0.00004932223,0.00007709405,0.000135376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987113,0.000803806,0.0001134171,0.00004874832,0.00002429978,0.0001279615,0.00005441171,0.00001077889,0.0001052342],"genre_scores_gemma":[0.9989856,0.00001732409,0.0005865706,0.000014627,0.00005466995,0.00002045318,0.0001287893,0.00001095597,0.000180995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007864819,"threshold_uncertainty_score":0.4454796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02234205455282872,"score_gpt":0.2376605425793838,"score_spread":0.2153184880265551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}