{"id":"W2047759469","doi":"10.1073/pnas.0607779104","title":"Crucial roles of <i>Foxa2</i> in mouse anterior–posterior axis polarization via regulation of anterior visceral endoderm-specific genes","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"FOXA2; Endoderm; Biology; Wnt signaling pathway; Transcription factor; Cell biology; Gene; Primitive streak; Gastrulation; Ectoderm; Chordate; Genetics; Embryogenesis; Vertebrate; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001504172,0.0002869093,0.0001351893,0.0002527083,0.0002098259,0.0003118339,0.0001198028,0.0002484119,0.001272571],"category_scores_gemma":[0.00009835933,0.0002246778,0.00021374,0.00006864907,0.0003211734,0.0001865288,0.0002227442,0.0005116601,0.0004257811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307084,"about_ca_system_score_gemma":0.0001707799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005260271,"about_ca_topic_score_gemma":0.0009228768,"domain_scores_codex":[0.9998481,0.00001937362,0.00001162051,0.0000441368,0.00003797826,0.00003870457],"domain_scores_gemma":[0.9998672,0.00001381518,0.00004304674,0.00001336187,0.00001101342,0.00005158579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006163712,0.000004069602,0.0002002812,0.000008603745,0.000001408164,0.00005690106,0.00000748685,0.00001693074,0.9990116,0.0001699296,0.00002343322,0.0004376827],"study_design_scores_gemma":[0.0000291541,0.00009143513,0.01425258,0.00000824845,0.00001315332,0.0006796713,0.00003251271,0.0005536942,0.9809007,0.0001288991,0.003304936,0.000005033615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919719,0.001025602,0.002878006,0.0001536788,0.00002478825,0.00001014525,0.0003105923,0.0001045731,0.003520699],"genre_scores_gemma":[0.9933647,0.0004287917,0.001502417,0.00008583648,0.00001037003,0.00001772885,0.0003727659,0.00005538865,0.004162087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272571,"threshold_uncertainty_score":0.004257143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199849270627239,"score_gpt":0.3050083589307595,"score_spread":0.2830098662244871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}