{"id":"W2047767458","doi":"10.1016/j.antiviral.2010.06.001","title":"Tissue culture drug resistance analysis of a novel HIV-1 protease inhibitor termed PL-100 in non-B HIV-1 subtypes","year":2010,"lang":"en","type":"article","venue":"Antiviral Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; McGill University; Centre Hospitalier de l’Université de Montréal; Jewish General Hospital","funders":"National Institutes of Health; National Institute for Health and Care Research","keywords":"Drug resistance; Virology; Biology; Mutation; Virus; Protease; Protease inhibitor (pharmacology); Recombinant DNA; Resistance mutation; Human immunodeficiency virus (HIV); Lentivirus; Genetics; Viral disease; Enzyme; Viral load; Gene; Reverse transcriptase; Polymerase chain reaction; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110659,0.000215525,0.0005996063,0.001167867,0.0001118935,0.0000372359,0.0002289302,0.0001543448,0.00009645897],"category_scores_gemma":[0.0004561571,0.0001637538,0.000141658,0.00274595,0.0002953882,0.0001459474,0.0001260869,0.0008171135,0.0001763316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041935,"about_ca_system_score_gemma":0.0003455083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001515203,"about_ca_topic_score_gemma":0.00182571,"domain_scores_codex":[0.9973539,0.0001041149,0.0004276824,0.0005189373,0.001002555,0.0005928627],"domain_scores_gemma":[0.9987206,0.000160802,0.00008544118,0.0005305662,0.000364445,0.0001381306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001277901,0.002471366,0.3767607,0.0003506691,0.0007996567,0.0005374323,0.006351038,6.74006e-7,0.5738676,0.0003772878,0.03479487,0.002410801],"study_design_scores_gemma":[0.006887408,0.0001832357,0.3052006,0.0007024949,0.0005062154,0.000004967856,0.001031517,0.0006945027,0.6555625,0.0000639427,0.0286599,0.0005027088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868997,0.00008914124,0.00003817463,0.004118184,0.00004432334,0.001119284,0.00007260848,0.00002484157,0.007593697],"genre_scores_gemma":[0.8479516,0.00003617458,0.002101147,0.00002045457,0.00008783236,0.0001251206,0.0001839806,0.00002197224,0.1494717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.141878,"threshold_uncertainty_score":0.6677687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02559275056519349,"score_gpt":0.3578019816375962,"score_spread":0.3322092310724027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}