{"id":"W2047823017","doi":"10.1016/j.neuropharm.2014.01.012","title":"UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances l-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset","year":2014,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto Western Hospital","funders":"Parkinson Canada; Edmond J. Safra Philanthropic Foundation; Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Dyskinesia; MPTP; Dopamine; Parkinsonism; Pharmacology; Marmoset; Levodopa; Parkinson's disease; Psychosis; Psychology; Medicine; Dopamine transporter; Serotonin; Internal medicine; Psychiatry; Dopaminergic; Disease; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006631665,0.0005909507,0.0006407377,0.0003969102,0.0004488154,0.0001897843,0.0009163181,0.0001703819,0.0001821284],"category_scores_gemma":[0.0001880332,0.0004542181,0.000096029,0.001168411,0.0005209942,0.000477246,0.0001406758,0.001122096,0.00006139706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005307325,"about_ca_system_score_gemma":0.00004718893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007806506,"about_ca_topic_score_gemma":0.0002065191,"domain_scores_codex":[0.9939131,0.002436944,0.000812961,0.00134301,0.0006065106,0.0008874591],"domain_scores_gemma":[0.9979657,0.0007689872,0.0003915708,0.0005886167,0.00006253661,0.0002226153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008439085,0.0004210686,0.03568969,0.00003465786,0.000003427075,0.0004671997,0.0003608248,0.00002009027,0.9509786,0.00001396928,0.0006160972,0.0105504],"study_design_scores_gemma":[0.004002746,0.001040037,0.2373856,0.00008084649,0.0001159627,0.0008067588,0.00009903741,0.0004029168,0.7378932,0.00001063766,0.01757994,0.0005823685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936146,0.00002864909,0.00002142576,0.001908843,0.002493985,0.001618447,0.00002550724,0.0002097572,0.00007879262],"genre_scores_gemma":[0.9920076,0.0002762055,0.0001715609,0.006601417,0.0002256578,0.000473233,0.000006374265,0.00009907124,0.000138942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2130855,"threshold_uncertainty_score":0.999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204727464432129,"score_gpt":0.3468496308264654,"score_spread":0.2948023561821441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}