{"id":"W2047823017","doi":"10.1016/j.neuropharm.2014.01.012","title":"UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances l-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset","year":2014,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Toronto Western Hospital","funders":"Parkinson Canada; Edmond J. Safra Philanthropic Foundation; Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Dyskinesia; MPTP; Dopamine; Parkinsonism; Pharmacology; Marmoset; Levodopa; Parkinson's disease; Psychosis; Psychology; Medicine; Dopamine transporter; Serotonin; Internal medicine; Psychiatry; Dopaminergic; Disease; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554023,0.0006805998,0.001016906,0.0006548036,0.0003758073,0.0004335135,0.0004976215,0.0008047651,0.001727026],"category_scores_gemma":[0.0003444185,0.0003744987,0.0004231066,0.0002884991,0.0007909811,0.0005132435,0.0002560696,0.001196369,0.0004142438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005357126,"about_ca_system_score_gemma":0.0004798714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003056888,"about_ca_topic_score_gemma":0.00761279,"domain_scores_codex":[0.9997351,0.00004629007,0.00002235427,0.00004120329,0.00004946498,0.0001055314],"domain_scores_gemma":[0.9997328,0.00002889217,0.00007199293,0.00002047605,0.00001465795,0.0001311447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002939151,0.0003042984,0.000616835,0.0000612478,0.00006369109,0.000283462,0.00005849078,0.000147106,0.9923939,0.0001391269,0.0001819792,0.002810758],"study_design_scores_gemma":[0.0004891136,0.01149884,0.01673965,0.00001538364,0.0002402771,0.001567536,0.0001627164,0.002305043,0.9651275,0.000141887,0.001669045,0.0000432137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986934,0.000361824,0.0001388969,0.00005925249,0.00001242248,0.00001066723,0.00009317015,0.00005503717,0.0005753619],"genre_scores_gemma":[0.9974036,0.0003407651,0.0004471885,0.00005680708,0.00001332317,0.00002506992,0.0003110283,0.00002265041,0.001379558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003056888,"threshold_uncertainty_score":0.006078184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204727464432129,"score_gpt":0.3468496308264654,"score_spread":0.2948023561821441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}