{"id":"W2047837456","doi":"10.1021/jo061339s","title":"Synthesis of Docetaxel and Butitaxel Analogues through Kinetic Resolution of Racemic β-Lactams with 7-<i>O</i>-Triethylsilylbaccatin III","year":2007,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"National Cancer Institute","keywords":"Kinetic resolution; Steric effects; Lactam; Chemistry; Stereochemistry; Resolution (logic); Docetaxel; Beta-lactam; Organic chemistry; Enantioselective synthesis; Catalysis; Antibiotics; Medicine; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005235275,0.0001232162,0.0004074521,0.00002987674,0.00003359939,0.000002315272,0.0001120782,0.00007975724,0.0002904964],"category_scores_gemma":[0.0001032368,0.00007464211,0.00006392782,0.0002080856,0.0002478782,0.00004652682,0.00002713506,0.0002356398,5.392774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007845386,"about_ca_system_score_gemma":0.0001629889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005276116,"about_ca_topic_score_gemma":0.00001111211,"domain_scores_codex":[0.9990408,0.00002683093,0.0004684817,0.00008063784,0.0002323109,0.0001509343],"domain_scores_gemma":[0.9985579,0.0003557233,0.0006420665,0.0001706541,0.0002032976,0.00007034417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002764235,0.0002326772,0.003522582,0.0002185981,0.0003314984,0.00002066472,0.0007426984,0.000003425178,0.9911529,0.000003769708,0.0004504181,0.0005565143],"study_design_scores_gemma":[0.002867355,0.0004364307,0.009470382,0.0002683252,0.00122865,0.001198064,0.0008089259,0.000004594984,0.9833288,0.00005951027,0.0002605632,0.00006840006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929667,0.004703837,0.0003111499,0.0006531277,0.00003435909,0.00008941616,0.000005219842,0.000004846762,0.001231363],"genre_scores_gemma":[0.9971039,0.001930906,0.0005416232,0.00004705589,0.0001521588,5.961386e-7,0.000002110102,0.00001372243,0.0002078873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007824119,"threshold_uncertainty_score":0.3180732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094170947934111,"score_gpt":0.2705639883380366,"score_spread":0.2596222788586955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}